A green synthesis of 1,2,3-triazolyl-pyridine hybrids and evaluation of their antibacterial activity

Raja, R.; Archana, Sivasubramaniyan; Dinesh, Murugan; Subbaiah, N Yella; George, Jaabil; Shanmugavelan, Poovan; Nagarajan, Sangaraiah; Ponnuswamy, Alagusundaram; Krishnamoorthy, Sujatha; Chandrasekaran, M.

doi:10.1007/s11164-016-2575-y

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…As per the literature survey, we noted that plenty of synthetic route exists for symmetrical twin bioactive moieties in single frame like bis triazole, bis pyrimidine and bis triazolyl pyrimidine [18][19][20][21][22][23][24][25][26] derivatives. The researchers primarily follow quite a few steps and prefer metallic catalyst for the synthesis the valuable symmetrical twin bio moieties.…”

Section: Introductionmentioning

confidence: 99%

A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids

Maheswari

Ponnuswamy

2023

Preprint

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Nitrogen-containing organic compounds play very vital roles in the research areas of organic chemistry, medicinal chemistry, and pesticidal chemistry. In recent times, the chemistry of heterocyclic triazole derivatives and 2-amino pyrimidine derivatives has attracted much attention owing to their versatile pharmacological properties1,2,3. Triazole, tetrazole, oxazole, imidazole and pyrazole are receiving much more attention due to their potential biological activities. A lot of fused heterocyclic ring owning pyrimidinepyrazole4, benzoxazole5, benzimidazole, pyrimidotriazipine6, have been described as efficient pharmacophores. Among the overhead, pyrimidine based fused pharmacophore7,8,9 plays a vital role for numerous biological activities such as analgesic10, anticonvulsant11, antiparkinsonian12, Anti bacterial13,14, anti-microbial15. They also serve as potential chemotherapeutic agents for various diseases16,17. Thus the synthesis of these type of pharmacophore is crucial now a days to our humanity.

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Section: Introductionmentioning

confidence: 99%

A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids

Maheswari

Ponnuswamy

2023

Preprint

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“…There are early reports on the ability of pyridines to bind with DNA/RNA and to form metal complexes . MCRs (multicomponent reactions) are potent processes used to facilitate the construction of druglike compounds, helping in drug discovery. , During the last decade, a hybridization approach was adopted to design 1,2,3-triazole-pyridine hybrids, and their synthetic and medicinal impacts were estimated. − Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. − Overexpression of Aurora B kinase occurred frequently during the process of hepatocarcinogenesis. , The investigation of the inhibition activity of Aurora B kinase on HepG2 cell invasion and migration and its role in hepatocellular carcinogenesis is well reported. , In the present work, in silico docking approach has been carried out to investigate docking interactions between triazolyl-pyridine hybrids and the target protein Aurora B kinase. Our results provide that the newly synthetic hybrid molecules could be targets for HCC treatment.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Anticancer Evaluation, Computer-Aided Docking Studies, and ADMET Prediction of 1,2,3-Triazolyl-Pyridine Hybrids as Human Aurora B Kinase Inhibitors

2021

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A novel series of 1,2,3-triazolyl-pyridine hybrids were prepared through the reaction of the triazole derivative (1) with the appropriate aldehyde (2a−g) and malononitrile or ethyl cyanoacetate in the presence of ammonium acetate in refluxed acetic acid. The chemical composition of the products was established on the basis of spectral and elemental analyses. Aurora B kinase is a protein with diverse biological actions in controlling tumorigenesis by inhibiting apoptosis and promoting proliferation and metastasis, making it an emerging target for diseases such as hepatocellular carcinoma (HCC). Alteration in the target protein expression causes unequal distribution of genetic information, causing HCC. The new compounds were tested for their antihepatic cancer activity, and some of them had strong efficacy against human hepatoblastoma (HepG2) cell lines.

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“…With this in mind, we have recently reported the synthesis of various bioactive hybrids linking 1,2,3‐triazole with many other heterocycles such as indoles, pyrazolines, N ‐acyl pyrazolines, pyrimidine‐2‐thiones, 2‐aminopyrimidines and pyridine from easily accessible 1,2,3‐triazole‐chalcones via environ‐friendly, greener pathways.…”

Section: Introductionmentioning

confidence: 99%

A Green and Efficient Synthesis of Bioactive 1, 2, 3 ‐ Triazolyl‐Pyridine/Cyanopyridine Hybrids via One‐Pot Multicomponent Grinding Protocol

et al. 2018

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A green and efficient synthesis of bioactive 1,2,3‐triazolyl‐pyridine/cyanopyridine hybrids has been achieved from easily accessible starting materials via one‐pot sequential multicomponent reaction under grinding strategy at room temperature in good to excellent yields. All the synthesized hybrids were evaluated for their antimicrobial activities against three human bacterial pathogens viz. Staphylococcus aureus, Salmonella typhi and Escherichia coli. The 1,2,3‐triazolyl cyanopyridine hybrids with 4‐chlorophenyl (5 c) and 2‐methylphenyl (5 e) substituents and the thiophenyl substituted 1,2,3‐triazolyl pyridine hybrid (5 s) showed remarkable activity better than tetracycline (standard drug). Also the selected compounds were screened for their antioxidant activity in the assay by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) method.

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A green synthesis of 1,2,3-triazolyl-pyridine hybrids and evaluation of their antibacterial activity

Cited by 10 publications

References 32 publications

A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids

A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids

Synthesis, Anticancer Evaluation, Computer-Aided Docking Studies, and ADMET Prediction of 1,2,3-Triazolyl-Pyridine Hybrids as Human Aurora B Kinase Inhibitors

A Green and Efficient Synthesis of Bioactive 1, 2, 3 ‐ Triazolyl‐Pyridine/Cyanopyridine Hybrids via One‐Pot Multicomponent Grinding Protocol

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