Soundscape is defined as the entire acoustic environment and the human responses to it. This review summarizes different human reactions to sound exposure, their development, prevalence, symptoms, comorbidities, methods for their assessment, and possible origins. The interpretation of sounds from the environment depends, not only on the characteristics of the sound itself, but also on the characteristics of the listener, their judgments, preferences, motivations, and emotional reactions to the sound or its source. Typical sound-related reactions are presented from two standpoints: population reactions, from the community perspective, and individual reactions, from the clinical perspective. Noise annoyance is a specific, unique, and typical psychological and physiological reaction to noise, which is assessed from the community perspective. Noise sensitivity, a stable personality trait, is at the basis of noise annoyance. Both noise annoyance and noise sensitivity play important roles in the development of other noise-related health disturbances. From the clinical perspective, hyperacusis and misophonia are the most distinctive individual responses to specific sounds. They may become so pronounced that they disturb one's physical and mental health, behavior, and functioning. Human reactions to sounds in the environment are widespread and well-investigated. This review goes beyond merely defining terminology in the domain of psychoacoustics; it may help health professionals understand human reactions to sound better. Further studies need to be directed towards developing methods for alleviating or treating the described reactions, but also towards creating a more pleasant acoustic environment for the purpose of protecting public health.