A Green Protocol for One-Pot Biginelli Condensation Catalyzed by Para Toulene Sulfonic Acid under Microwave Irradiation

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity

“…19 An environmentally benign synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones and thiones has been reported by Lal and co-workers from formylchromone, urea/thiourea and a variety of substituted acetophenones (Biginelli reaction) by applying p -TSA as a catalyst under microwave irradiation (Scheme 12). 20 In comparison to conventional heating, the current approach has produced outstanding yields. Also, in contrast to the traditional Biginelli reaction conditions, all the compounds have been separated by simple filtration with only 15–20 min of reaction time.…”

Thiopyrimidine‐5‐carbonitrile Derivatives as VEGFR‐2 Inhibitors: Synthesis, Anticancer Evaluation, Molecular Docking, ADME Predictions and QSAR Studies

“…[13] Many tumors depend on the activation of RAF, hence the development of anticancer drugs is necessary to inhibit this activation. [14] Heterocyclic compounds, bearing the pyrimidine scaffold, are known for exhibiting/displaying interesting biological activities, such as antitumor activity, [15][16][17] bactericidal, [18,19] fungicidal, [20] antiviral, [21] anti-amoebic, [22] antioxidant [23,24] and anti-inflammatory. [25,26] One of these compounds, 2-thioxopyrimidine derivatives which were brought into research scope by many synthetic-biochemists.…”