A green polyol approach for the synthesis of Cu₂O NPs adhered on graphene oxide: a robust and efficient catalyst for 1,2,4-triazole and imidazo[1,2-a]pyridine synthesis

Abstract

Cu2O NPs immobilized on graphene oxide are used as a heterogeneous catalyst for the synthesis of a series of 1,2,4-triazoles and imidazo[1,2-a]pyridines under solvent-free conditions.

Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines from Enaminonitriles

“…This cascade reaction proceeds via C-N coupling, followed by Boulton–Kartritzky rearrangement [ 27 ]. In 2022, Cao and coworkers reported the reaction of N -iminoisoquinolinium ylides with dioxazolone as an acyl nitrile source in the presence of copper acetate, providing 1,2,4-triazolo[1,5- a ]pyridines via C-H amidation and cyclization [ 28 ], and so on [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Despite the efficiency of these methods in several aspects, there are still some limitations, including the use of solvent in large quantities, longer reaction times, multistep processes, and, in several cases, the requirement for either metal or external catalysts, which will come out as chemical hazards.…”