A green LC-MS/MS for energetically assessing an imperative muscle relaxant combination: A clinical pharmacokinetic study in human plasma

Helmy, Marwa I.; Nessim, Christine K.; Hamd, Mohamed A. El

doi:10.1016/j.microc.2024.110848

Cited by 1 publication

(1 citation statement)

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“…The final assessment score ranges from 0 to 1, where scores closer to 1 are shown in green to denote higher sustainability and scores near 0 are displayed in red, indicating lower sustainability. 56 In this study, we used AGREEprep to assess the environmental impact of preparing spiked human plasma samples. The developed method excelled in several areas, including the elimination of 2) No organic solvents or heating required: the method's reliance on Britton-Robinson buffer instead of organic solvents and its operation at laboratory temperatures minimize environmental and health hazards, as well as energy consumption, adhering to green chemistry principles.…”

Section: Resultsmentioning

confidence: 99%

Bridging Pharma and Sustainability: Green Electrochemical Analysis of Antiparkinsonian Drug in Pharmaceuticals and Plasma, Aligned with United Nations Goals via the NQS Index

Helmy,

El Hamd,

Obaydo

et al. 2024

J. Electrochem. Soc.

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This study presents a sustainable electrochemical investigation of pramipexole (PRA) in pharmaceuticals and human plasma, using cyclic and differential pulse voltammetry. Key parameters, including potential range, buffer pH, accumulation period, and scan rate were optimized, establishing efficient voltammetric methods for PRA analysis. The analytical range was 0.60 – 12.00 μg/mL, with a detection limit of 0.14 μg/mL and a correlation coefficient of 0.9998. Recovery rates for PRA ranged from 98.60 ± 0.26% to 101.33 ± 0.38%, validating the methodology's applicability in human plasma with an average recovery of 99.25 ± 0.45%. The study highlights the environmental sustainability of the developed voltammetric electrode, evaluated through SWOT analysis, and assesses the greennees impact using tools like Complementary Green Analytical Procedure Index (ComplexGAPI), Analytical greenness (AGREE) and Analytical greenness for sample preparation (AGREEprep). Significantly, this work aligns with numerous United Nations Sustainable Development Goals (UN-SDGs), specifically goals 3, 4, 5, 7, 9, 11, 12, 13, 14, 15, and 17, illustrating our commitment to sustainable pharmaceutical research. The sustainability of the method was further quantified using the newly introduced Need, Quality, Sustainability (NQS) index, demonstrating significant alignment with sustainable analytical practices.

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Section: Resultsmentioning

confidence: 99%