A green EC/ECL dual-mode biosensing platform for detection of Vibrio parahaemolyticus

Zhai, Tingting; Zhang, Qingqing; Yang, Fan; Zhou, Huiqian; Bai, Lipeng; Hao, Tingting; Guo, Zhiyong; Chen, Zhongxiu

doi:10.1016/j.snb.2024.136010

Sensors and Actuators B: Chemical

2024

DOI: 10.1016/j.snb.2024.136010

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A green EC/ECL dual-mode biosensing platform for detection of Vibrio parahaemolyticus

Tingting Zhai,

Qingqing Zhang,

Fan Yang

et al.

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Cited by 3 publications

References 39 publications

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Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox

Yang,

Zheng,

Wang

et al. 2024

Advanced Science

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Dual‐mode readout platforms with colorimetric and electrochemiluminescence (ECL) signal enhancement are proposed for the ultrasensitive and flexible detection of the monkeypox virus (MPXV) in different scenes. A new nanotag, Ru@U6‐Ru/Pt NPs is constructed for dual‐mode platforms by integrating double‐layered ECL luminophores and the nanozyme using Zr‐MOF (UiO‐66‐NH2) as the carrier, which not only generates enhanced ECL and colorimetric signals but also provide greater stability than that of commonly used nanotags. Dual‐mode platforms are used within 15 min from the “sample in” to the “result out” steps, without nucleic acid amplification. The colorimetric mode allows the screening of MPXV with the visual limit of detection (vLOD) of 0.1 pM (6 × 108 copies µL−1) and the ECL mode supports quantitative detection of MPXV with an LOD as low as 10 aM (6 copies·µL−1), resulting in a broad sensing range of 60 to 3 × 1011 copies·µL−1 (10 orders of magnitude). Validation is conducted using 50 clinical samples, which is 100% concordant to those of quantitative polymerase chain reaction (qPCR), indicating that Ru@U6‐Ru/Pt NPs‐based dual‐mode sensing platforms showed great promise as rapid, sensitive, and accurate tools for diagnosis of the nucleic acid of MPXV and other infectious pathogens.

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Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox

Yang,

Zheng,

Wang

et al. 2024

Advanced Science

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Detection of pathogenic bacteria with nanozymes-based colorimetric biosensors: Advances, challenges and future prospects

Mansouri

2024

Microchemical Journal

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Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors

Abbasi,

Hu,

Zhang

et al. 2024

Bioengineering

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Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, efficient, and miniaturized analysis at the point of need. These LOC platforms leverage optical phenomena such as chemiluminescence and electrochemiluminescence to achieve real-time detection and quantification of analytes, making them ideal for applications in medical diagnostics, environmental monitoring, and food safety. Various optical detectors used for detecting chemiluminescence are reviewed, including single-point detectors such as photomultiplier tubes (PMT) and avalanche photodiodes (APD), and pixelated detectors such as charge-coupled devices (CCD) and complementary metal–oxide–semiconductor (CMOS) sensors. A significant advancement discussed in this review is the integration of optical biosensors with pixelated image sensors, particularly CMOS image sensors. These sensors provide numerous advantages over traditional single-point detectors, including high-resolution imaging, spatially resolved measurements, and the ability to simultaneously detect multiple analytes. Their compact size, low power consumption, and cost-effectiveness further enhance their suitability for portable and point-of-care diagnostic devices. In the future, the integration of machine learning algorithms with these technologies promises to enhance data analysis and interpretation, driving the development of more sophisticated, efficient, and accessible diagnostic tools for diverse applications.

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A green EC/ECL dual-mode biosensing platform for detection of Vibrio parahaemolyticus

Cited by 3 publications

References 39 publications

Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox

Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox

Detection of pathogenic bacteria with nanozymes-based colorimetric biosensors: Advances, challenges and future prospects

Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors

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