A Green Catalyst Fe(OTs)₃/SiO₂ for theSynthesis of 4‐Pyrrolo‐12‐oxoquinazolines

Abstract

An efficient and eco‐friendly diversity‐oriented synthetic protocol has been presented to synthesize structurally versatile drug‐like molecules under solvent‐free grinding in the presence of Fe(OTs)3/SiO2 as a catalyst. The use of Fe(OTs)3/SiO2 as a recyclable and reusable catalyst has been explored in the synthetic domino protocol involving one‐pot, three component reaction for the synthesis of 4‐pyrrolo‐12‐oxoquinazolines with special features of the protocol like high atom‐economy, operational simplicity, short reaction time and high selectivity with excellent yields.

An ultrasound assisted synthesis of spirooxindolo-1,2,4-oxadiazoles via [3+2] cycloaddition reaction and their anti-cancer activity

“…Therefore, in this paper, we describe the use of ultrasound to aid in the [3+2] cycloaddition process to produce spirooxindolo-1,2,4-oxadiazoles, which were then examined for their anti-cancer potential as part of our continuing research into green chemistry and bio-active spirooxindoles. 24,25,26 AUTHOR(S) Figure 1. Design strategy for spirooxindolo-1,2,4-oxadiazoles for anti-cancer activity having 1,2,4-oxadiazole, oxindole, quinoline moieties as pharmacophores.…”

Synthesis, Anti-mycobacterial activity, Molecular Docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation

“…There is no literature on the synthesis of spiroquinoxaline-1,2,4oxadiazoles utilizing ultrasonic irradiation that we are aware of now. As a result, we disclose the use of ultrasound to help in the [3 + 2] cycloaddition process to make spiroquinoxaline-1,2,4-oxadiazoles as part of our ongoing study into green chemistry and bio-active spiroquinoxaline-1,2,4-oxadiazoles [28][29][30][31].…”