A green approach for the synthesis of 2-substituted benzoxazoles and benzothiazoles via coupling/cyclization reactions

Advances in the synthetic strategies of benzoxazoles using 2-aminophenol as a precursor: an up-to-date review

“…The synthesis of benzoxazole derivatives ( 3 ) by a condensation reaction between 2-aminophenol ( 1 ) and aldehydes ( 2 ) using a magnetic nanomaterial Fe 3 O 4 -supported Lewis acidic ionic liquid (LAIL@MNP) was investigated by Nguyen and co-workers. 61 In this study, the reactants were sonicated under solvent-free conditions at 70 °C for 30 min to deliver moderate to high yields. Reusability of the catalyst, easy workup, solvent-free conditions, shorter reaction time, and a green pathway are advantages of this process (Scheme 6; method 2).…”

Fe3O4@ABA-aniline-CuI nanocomposite as a highly efficient and reusable nanocatalyst for the synthesis of benzothiazole-sulfide aryls and heteroaryls

“…43,44 A useful central structure, benzothiazole forms part of the molecular structure of a large number of biological molecules, drugs, natural products and industrial chemicals. [45][46][47] Recently, applications of benzothiazoles with different biological activities, such as anti-viral, anti-tumor, anti-fungal, anti-bacterial and anti-cancer activities, have been discovered. 43,46 In the past few decades, the formation of carbon-sulfur bonds has been widely studied by chemists.…”

“…[45][46][47] Recently, applications of benzothiazoles with different biological activities, such as anti-viral, anti-tumor, anti-fungal, anti-bacterial and anti-cancer activities, have been discovered. 43,46 In the past few decades, the formation of carbon-sulfur bonds has been widely studied by chemists. Studying diaryl suldes is important in organic synthesis because a large number of natural and medicinal products contain sulde scaffolds.…”