A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent

Gao, Ming‐Zhu; Cui, Qi; Wang, Litao; Meng, Yao; Yu, Linghui; Li, Yanyan; Fu, Yujie

doi:10.1016/j.microc.2020.104598

Cited by 98 publications

(39 citation statements)

References 50 publications

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“…For the recovery of the extracted bioactive compounds, in particular the flavonoids, there are several approaches such as solid phase extraction (SPE) [47,164], macroporous resin adsorption [79,103,111,143,144,148], anti-solvent precipitation [107,164,165], back-extraction [122], and adsorption chromatography [166] that have been evaluated to date.…”

Section: Recovering Of the Bioactive Compounds From The Des/nades Extmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

120

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Section: Recovering Of the Bioactive Compounds From The Des/nades Extmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

120

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“…At the same time, deep eutectic solvents as extractants of polyphenolic compounds from tomato pomace have not been studied. Nevertheless, as per the literature survey, some works indicate that the use of choline chloride-based DES is as an effective means for the extraction of polyphenolic compounds from pomegranate peels [39], virgin olive oil [40], mulberry(Morus alba L.) leaves (Ming-ZhuaGet al 2020) [41], orange peel waste [42]and for many other types of waste.…”

Section: Introductionmentioning

confidence: 99%

Extraction of phenolic compounds from tomato pomace using choline chloride–based deep eutectic solvents

2021

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The objective of this research was to investigate the efficacy of deep eutectic solvents (DESs)to extract polyphenolic compounds from tomato pomace with the assistance of ultrasound. The phytochemical constituents of tomato pomace extracts (TPE) were verified with a combination of high-performance liquid chromatography coupled with diode array detection and tandem mass spectrometry (HPLC-DAD-MS) and FTIR analysis. The extracted phenolic compounds from tomato pomace were quantified by Folin-Ciocalteu method. The predominant components in tomato pomace extracts were phenolic acids and flavanols. Chlorogenic acid was detected as the main phenolic compound in tomato extracts. The redox behavior of tomato pomace extracts was evaluated by means of cyclic voltammetry. Antioxidant activities of the obtained extracts were determined using the DPPH and ABTS scavenging assays. The reduction capacity of the extracts was assessed using ferric reducing power (FRAP) and phosphomolybdenum (PM) assays. extracts with DESs are characterized by the highest level of antioxidant activity. Theoretical study based on quantum chemistry/molecular modeling were performed to confirm the antioxidants capacity of compounds of tomato pomace extracts. Quantum chemical descriptors such as the frontier orbital energies (E HOMO and E LUMO ), the energy gap between E HOMO and E LUMO (ΔE), hardness, and electrophilicity index have been calculated and discussed.

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“…Moreover, the proposed procedure is more sustainable, since the extraction phase consists of an aqueous solution of an IL-based surfactant at a quite low concentration level (less than 10 mg of IL is required in each extraction). Besides, the absence of organic solvents in the entire procedure, in comparison with other common MA-SLE methods reported in the literature for plant analysis [23,25,[40][41][42][43][44][45][46], makes it comply with one of the most important requirements set by the GAC. Although other MA-SLE methods using ILs have been previously proposed in the literature for the extraction of bioactive compounds from plant material, those methods usually incorporate a cleanup step prior the injection in the analytical system [24,47,48], or they require the dilution of the extract with organic solvents [49][50][51][52].…”

Section: Comparison Between Ua-sle and Ma-sle Methods Using Italian Cumentioning

confidence: 99%

Sustainable Micro-Scale Extraction of Bioactive Phenolic Compounds from Vitis vinifera Leaves with Ionic Liquid-Based Surfactants

et al. 2020

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This paper proposes a new sustainable and simple strategy for the micro-scale extraction of phenolic compounds from grapevine leaves with analytical purpose. The method is based on a microwave-assisted solid-liquid extraction approach (MA-SLE), using an aqueous solution of an ionic liquid (IL)-based surfactant as extraction phase. The method does not require organic solvents, nor any clean-up step, apart from filtration prior to the injection in the analytical system. Two IL-based surfactants were evaluated, and the method was optimized by using experimental designs, resulting in the use of small amounts of sample (100 mg) and extraction phase (2.25 mL), low concentrations of the selected 1-hexadecyl-3-butyl imidazolium bromide IL (0.1 mM), and 30 min of extraction time. The proposed methodology was applied for the determination of the polyphenolic pattern of six different varieties of Vitis vinifera leaves from the Canary Islands, using high-performance liquid chromatography and photodiode array detection for the quantification of the compounds. The proposed MA-SLE approach was greener, simpler, and more effective than other methods, while the results from the analysis of the leaves samples demonstrate that these by-products can be exploited as a source of natural compounds for many applications.

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A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent

Cited by 98 publications

References 50 publications

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Extraction of phenolic compounds from tomato pomace using choline chloride–based deep eutectic solvents

Sustainable Micro-Scale Extraction of Bioactive Phenolic Compounds from Vitis vinifera Leaves with Ionic Liquid-Based Surfactants

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