A Greek multicenter study comparing the clinical and immunologic phenotypes between adult and juvenile- onset lupus

Nalbanti, Panagiota; Stefanidou, S; Alfantaki, Sapfo; Siamopoulou, Antigoni; Trachana, Maria; Galanopoulou, Vasiliki; Pratsidou-Gerts, P; Farmaki, Evangelia; Papachristou, Fotis; Garyphallos, Alexandros; Kanakoudi-Tsakalidou, F

doi:10.1186/1546-0096-9-s1-p245

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“…SLE is more common in women of reproductive age but can develop at any age, with 10-20% of cases occurring in children and adolescents under 18 [4]. It was reported that juvenile lupus erythematosus is far more severe than the adult variant [5]. Up to ten years after the first diagnosis, dizziness, and new system/organ involvement may emerge after a protracted period of remission [5].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of oral mucosal lesions in patients with systemic Lupus Erythematosus: a systematic review and meta-analysis

Du,

Qian,

Zhang

et al. 2023

BMC Oral Health

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Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause a range of symptoms, including oral mucosal lesions (OMLs). The prevalence of OMLs in SLE patients and their associated factors have been studied in various regions, but the results are inconsistent. This study aims to evaluate the prevalence of OMLs in patients with SLE. Methods Observational studies of OML prevalence in SLE patients published before 2022 were retrieved from PubMed, Embase, Web of Science, Google Scholar, and the Cochrane Library without language restriction. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ). Results Our meta-analysis included 113 studies with a total of 53,307 SLE patients. We found that the prevalence of OMLs in SLE patients was 31% (95% CI: 28%, 35%), with oral ulcers being present in 30% of SLE patients (95% CI: 26%, 33%). Subgroup analysis showed that the prevalence of OMLs varied significantly by region, disease activity, and sample size (p ≤ 0.01). However, gender and year of publication had little effect on the prevalence of OMLs (p = 0.78 and 0.30, respectively). Oral ulcers were significantly associated with age of onset (p = 0.02), geographic location (p < 0.01), and race (p < 0.01). We also found that the prevalence of oral erythema was 9%, oral candidiasis was 9%, petechiae was 8%, cheilitis was 6%, and white plaque was 3%. Conclusions Our analysis showed that the prevalence of OMLs varied significantly by region and disease activity, and child-onset patients of Indian, Malay, and Caucasian descent were more likely to have oral ulcers. The high prevalence of OML in SLE patients emphasizes the importance of regular oral examination and management in the comprehensive care of individuals with SLE.

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Section: Introductionmentioning

confidence: 99%

“…It was reported that juvenile lupus erythematosus is far more severe than the adult variant [5]. Up to ten years after the first diagnosis, dizziness, and new system/organ involvement may emerge after a protracted period of remission [5]. Late-onset SLE, which starts after 50 years of age, accounts for 2-20% of all SLE cases [6,7].…”

Section: Introductionmentioning

confidence: 99%