Abstract:The mef(A)‐ and its subclass mef(E) systems had long been considered to constitute one of the primary macrolide‐resistant mechanisms in Streptococcus pyogenes. However, we have previously demonstrated that the msr(D) gene located immediately downstream of the mef(A)/mef(E) genes plays a predominant role in these systems. In previous studies, furthermore, mef(A)‐associated msr(D)10‐85 of an S. pyogenes strain (10‐85) exhibited a greater increase in clarithromycin minimum inhibitory concentration (MIC) than mef(… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.