A great imitator in adult cardiology practice: congenitally corrected transposition of the great arteries

Agarwal, Anushree; Samad, Fatima; Kalvin, Lindsey; Bush, Michelle; Tajik, A. Jamil

doi:10.1111/chd.12453

Cited by 8 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is very limited experience of late physiologic repair of ccTGA. 10 This case presents a combination of unique features in terms of patient age, degree of cyanosis and symptoms severity, illustrating how patient-specific characteristics should guide a tailored treatment, targeting the dominant mechanism of disease. In particular, from the pathophysiologic point of view, the combination of large VSD and severe PS allowed both ventricles to properly develop, granting a balanced circulation and preventing the occurrence of pulmonary vascular disease.…”

Section: Discussionmentioning

confidence: 99%

A case report of late physiologic repair of congenitally corrected transposition of the great arteries and pulmonary stenosis in a severely cyanotic patient: better late than never

Ferrero

Chessa

Varrica

et al. 2021

European Heart Journal - Case Reports

View full text Add to dashboard Cite

Background Patients with congenitally corrected transposition of great arteries (ccTGA) not infrequently seek medical attention for the first time late in life. Optimal management of natural history ccTGA is debated and must be tailored. Case summary A 38 years old male patient was referred to our centre because of severe cyanosis and worsening dyspnoea. Investigations disclosed: situs solitus, mesocardia, double discordance, large ventricular septal defect (VSD), severe pulmonary stenosis, no significant atrioventricular valves regurgitation. The patient underwent physiologic repair: VSD closure, placement of a left ventricle to pulmonary artery conduit and epicardial atrio-biventricular pacemaker implantation. The conduit was intentionally undersized to promote tricuspid valve continence. Postoperative course was uneventful, trans-thoracic echocardiography showed good biventricular function without significant tricuspid regurgitation. At one month after discharge the patients is in NYHA class II. Discussion Management of late presenter patients with ccTGA depends on the associated lesion and estimation of surgical risk. In selected patients markedly symptomatic physiologic repair is a rationale option, providing a normal saturation and biventricular circulation with a significantly lower surgical risk as compared with anatomic repair.

show abstract

Section: Discussionmentioning

confidence: 99%

A case report of late physiologic repair of congenitally corrected transposition of the great arteries and pulmonary stenosis in a severely cyanotic patient: better late than never

Ferrero

Chessa

Varrica

et al. 2021

European Heart Journal - Case Reports

View full text Add to dashboard Cite

show abstract

“…Thus, early clinical recognition is crucial to prevent adverse consequences. Other forms of presentation include arrhythmias, abnormal cardiovascular signs like dyspnea, palpitations, murmurs, and an abnormal electrocardiogram or chest radiography [ 13 , 14 ] .…”

Section: Presentation and Diagnosismentioning

confidence: 99%

“…However, this is not the case for all patients. Complete heart block is also seen, may be found incidentally or in symptomatic patients, and may be the first clue to diagnosis [ 13 ] .…”

Section: Bedside Findingsmentioning

confidence: 99%

Congenitally Corrected Transposition of the Great Arteries in the Adult

Amaral¹,

Valente²,

Manso³

et al. 2022

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Introduction Congenitally corrected transposition of the great arteries (CCTGA) is a rare anomaly. Current data available regarding adult cases is derived from small series, information simultaneously presented in pediatric publications, and one classical multicenter study. This review, not aimed to exhaust the subject, has the purpose to examine the literature addressing presentation, diagnostic methodology, and management of afflicted adult patients. Methods A comprehensive search was undertaken in three major databases (PubMed, Cochrane, SciELO), using the keywords “congenitally corrected transposition of the great arteries” and “adults”. Relevant articles in English, Spanish, and Portuguese were extracted and critically appraised in this review. Steps for study selection were: (1) identification of titles of records through databases searching, (2) removal of duplicates, (3) screening and selection of abstracts, (4) final inclusion in the study. Results Four hundred sixty-five publications on CCTGA in adult patients were retrieved, and 166 were excluded; 299 studies were used for this review including 76 full-text articles, 70 studies related to general aspects of the subject, and, due to the small number of publications, 153 case reports. Sixty-one articles referring to combined experiences in pediatric and adult patients and judged to be relevant, but retrieved from another sources, were also included. Conclusion Albeit clinical presentation and diagnostic criteria have been well stablished, there seems to be room for discussion related to clinical and surgical management of CCTGA in adults. Considering the rarity of the disease, well designed multicenter studies may provide answers.

show abstract

“…The crux of the heart is another anatomical reference that should be evaluated to differentiate CCTGA from the criss-cross heart. Finally, the position of the aorta and pulmonary artery should be assessed to record the parallel presentation of both structures and make the final diagnosis [5].…”

Section: Introductionmentioning

confidence: 99%

Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

Luna-Alvarez-Amezquita¹,

Armenta-Moreno²,

Berarducci³

et al. 2021

WJCD

View full text Add to dashboard Cite

Introduction: Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart disease that encompasses an atrioventricular and ventriculoarterial discordance and accounts for less than 1 percent of congenital heart diseases. Objective: To present an atypical case of a man with complex congenital heart disease and conduction anomalies. Case Presentation: This is a case of a 34-year-old patient who came to the hospital with 1 week of dyspnea on exertion and episodes of lipothymia. The patient was referred to our hospital after an electrocardiogram from his primary care with evidence of blocked atrial fibrillation. During the initial evaluation blocked atrial fibrillation was confirmed with a rescue ventricular rate of 38 bpm. A magnetic resonance confirmed the presence of the atrioventricular and ventriculoarterial discordance, the aorta had a left anterior position, perimembranous ventricular septal defect with a right to left shunt, biventricular systolic dysfunction, moderate tricuspid, and mitral regurgitation, interventricular septal intramyocardial and biatrial fibrosis, left atrial dilation, and dilation of the pulmonary artery. After pacemaker placement, the patient has an improvement in his clinical symptoms and quality of life. Conclusions: Cardiac arrhythmias are CCTGA's leading cause of death, mostly ventricular tachycardia, and atrial fibrillation. Right bundle branch block is a previously unreported and potentially very rare presentation of this disease. This, added to the fact that our patient was diagnosed at an advanced age, but without symptoms of heart failure, makes him an atypical case of CCTGA, with new potential treatment options.

show abstract

A great imitator in adult cardiology practice: congenitally corrected transposition of the great arteries

Cited by 8 publications

References 27 publications

A case report of late physiologic repair of congenitally corrected transposition of the great arteries and pulmonary stenosis in a severely cyanotic patient: better late than never

A case report of late physiologic repair of congenitally corrected transposition of the great arteries and pulmonary stenosis in a severely cyanotic patient: better late than never

Congenitally Corrected Transposition of the Great Arteries in the Adult

Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

Contact Info

Product

Resources

About