A gravimetric technique for evaluating flow continuity from two infusion devices

Can J Anesth/J Can Anesth

Hug

Neff

et al. 2000

Section: Methodsmentioning

confidence: 99%

Syringe size and flow rate affect drug delivery from syringe pumps

Can J Anesth/J Can Anesth

Hug

Neff

et al. 2000

“…Fluid delivery into the sampling glass was measured gravimetrically using an electronic balance with a sensitivity of 0.0001 g (AG 204‐Delta‐Range, Mettler Toledo, Schwerzenbach, Switzerland) [4]. The data output of the balance was sampled at 1 Hz using purpose‐written software (MCPS V2.6‐CAD, Software GmbH, Mönchengladbach, Germany).…”

Section: Methodsmentioning

confidence: 99%

The effects of syringe plunger design on drug delivery during vertical displacement of syringe pumps

Fischer

Neff³

et al. 2000

Anaesthesia

SummaryFluid delivery from four types of commercially available 50-ml syringes was measured using an electronic balance at an infusion rate of 1 ml.h 21 . Retrograde aspiration volume and zero-drug delivery time were recorded after lowering the syringe pump by 50 cm. Syringe compliance was calculated from the volume of bolus released after occlusion at 100 mmHg. Zero-drug delivery times differed significantly between syringes, ranging from [mean (SD)] 3.26 (0.40) min to 6.38 (0.56) min (F 55.5, d.f. 3/20, p , 0.0001). Syringe compliance correlated well with aspiration volume (Pearson r 2 0.92, p , 0.001) and zero-drug delivery time (r 2 0.90, p , 0.001). Syringe design affected the internal syringe compliance. All syringes were associated with potentially relevant zerodrug delivery times after moderate vertical displacement. To minimise this risk, vertical displacement of syringe pumps delivering highly vasoactive drugs should be avoided.

“…The stopcock was immediately reopened (Figure 1c). The resulting infusion bolus, which overflowed into the sampling glass, was measured gravimetrically (10) using an electronic balance (sensitivity=0.01 g; PG 5002‐S, Delta‐Range, Mettler Toledo, Schwerzenbach, Switzerland). The additional influence of the infusion line on occlusion time and infusion bolus was assessed by closing the distal stopcock (Figure 1d) and reopening (Figure 1e) after reaching the occlusion alarm pressure (230 mmHg).…”

Section: Methodsmentioning

confidence: 99%

Impact of infusion line compliance on syringe pump performance

Neff

Gerber

et al. 2000

Pediatric Anesthesia

To determine the impact of infusion line compliance on the time to occlusion alarm (occlusion time) and the size of the subsequent occlusion release bolus, we studied three different infusion lines in combination with a 50-ml and 10-ml syringe. The mean occlusion time of the 50-ml syringe amounted to 20.3 +/- 0.28 min and increased to 26.2 +/- 0.19 min with the infusion with the infusion line yeielding the largest compliance (P<0.0001). The mean occlusion time of the 10-ml syringe was 2.5 +/- 0.75 min and showed a 2.7-fold variation with the three infusion lines (2.6+/-0.08, 5.6 +/- 0.28 and 6.9 +/- 0.35 min, respectively; P<0.0001). Occlusion times correlated strongly to be calculated estimated compliance of the syringe-infusion line assembly (Pearson's r=0.998, P<0.0001). Infusion line compliance has an important impact on time to occlusion, particularly when using small, low compliant infusion pump syringes.