A graphene oxide-loaded processed pyritum composite hydrogel for accelerated bone regeneration via mediation of M2 macrophage polarization

Shi, Changcan; Yu, Yinting; Wu, Hongjuan; Liu, Huanjin; Guo, Mengyu; Wang, Wenxin; Wang, Dan; Wei, Chenxu; Zhai, Hua‐Jin; Yan, Guoquan; Chen, Zhipeng; Cai, Ting; Li, Weidong

doi:10.1016/j.mtbio.2023.100753

Cited by 8 publications

(2 citation statements)

References 46 publications

(48 reference statements)

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“…This increased anti-inflammatory factors (IL-4, IL-10, and TGF-β), which in turn promoted the proliferation and osteogenic differentiation of BMSCs in vitro. The results further verify the anti-inflammatory effect of PP/GO@PEGDA/CMC in promoting bone regeneration in in vivo experiments [38]. Therefore, GO-based nanocomposites can regulate the immune microenvironment by promoting the polarization of M1 to M2-type macrophages and the secretion of anti-inflammatory factors, thereby promoting bone tissue repair.…”

Section: Promoting Bone Repair Through Immune Regulation: the Potenti...supporting

confidence: 70%

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Zhou,

Chen,

Zhang

et al. 2024

Nanomaterials

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Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing osteoporotic fractures. It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages in tissue engineering due to their excellent biocompatibility, mechanical properties, and osteoinductive abilities. Based on that, GO-nanocomposites have garnered significant attention and hold promising prospects for bone repair applications. This paper provides a comprehensive insight into the properties of GO, preparation methods for nanocomposites, advantages of these materials, and relevant mechanisms for osteoporotic fracture applications.

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Section: Promoting Bone Repair Through Immune Regulation: the Potenti...supporting

confidence: 70%

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Zhou,

Chen,

Zhang

et al. 2024

Nanomaterials

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“…Li et al prepared a processed pyritum (PP) loaded with GO in combination with PEGDA and CMC to successfully prepare a novel composite hydrogel (PP/GO@PEGDA/CMC). 133 The results showed that PP/GO@PEGDA/CMC had good immunomodulatory effects, significantly promoting M2 polarization and increasing the levels of anti-inflammatory factors (interleukin (IL)-4, IL-10 and transforming growth factor-β). This immunomodulatory effect was in turn able to promote osteoblast differentiation.…”

Section: Classification Of Hydrogels For Bone Healingmentioning

confidence: 99%

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Zhang,

Qi,

Zhang

et al. 2024

Biomater. Sci.

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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A graphene oxide-loaded processed pyritum composite hydrogel for accelerated bone regeneration via mediation of M2 macrophage polarization

Cited by 8 publications

References 46 publications

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

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