A Good Alternative to Reduce the Kidney Shortage

Abstract

Reducing the incidence of acute rejection and shortening ischemia time are conditions needed to guarantee a long graft survival of kidneys from NHB donors.

Clinical Results of an Organ Procurement Organization Effort to Increase Utilization of Donors after Cardiac Death

“…Renal function as evidenced by serum creatinine was quite good 2 years after transplantation. Only the high rate of delayed function stands out as an inferior outcome associated with the use of these kidneys, this outcome is similar to what has been reported elsewhere (1)(2)(3)(4)6).…”

“…A number of investigators have reported excellent short-term outcomes using these donors (1)(2)(3)(4)(5)(6), and several different organ procurement organizations have demonstrated 10 -15% growth in organ donation as a result of the use of these donors.…”

“…The procurement techniques themselves have not been fully standardized in the transplant community. Lastly, although short-term outcomes have generally been quite acceptable, kidneys obtained from DCD donors exhibited high rates of delayed graft function (2)(3)(4)6), reports of truly longterm outcomes are few (9,10), and some controversy still exists over how these organs should be considered in the overall allocation schema.…”

Outcome of Kidney Transplantation From Nonheart-Beating Versus Heart-Beating Cadaveric Donors

“…It includes the total number of patients, the number of studies used to evaluate each outcome, the summary statistic of OR or WMD, their calculated 95%CI, the P value, and a test of heterogeneity between the studies. Warm ischemia time was reported by seven studies (10,11,13,15,17,23,24) of 1280 patients. NHBD displayed a significantly longer WIT by 24 min (95% CI 20.43Ϫ27.80; PϽ0.001).…”

Laparoscopic Aortorenal Bypass in an Acute Porcine Model under Warm Ischemia: Feasibility Study and Resident Training Module

“…[20][21][22] The two previous groups that performed feasibility studies of LARB in the porcine model used either infusion of hypothermic saline into the renal artery or a bag of ice on the anterior kidney for hypothermia. [11][12][13] Although renal temperatures were not measured to confirm the efficacy of these measures, functional and histologic outcomes were favorable despite mean ischemia times of 49 or 61 minutes and times as long as 88 minutes (Table 3).…”