A Gold Standard Dataset for Lineage Abundance Estimation from Wastewater
Jannatul Ferdous Moon,
Samuel Kunkleman,
William Taylor
et al.
Abstract:During the SARS-CoV-2 pandemic, genome-based wastewater surveillance sequencing has been a powerful tool for public health to monitor circulating and emerging viral variants. As a medium, wastewater is very complex because of its mixed matrix nature, which makes the deconvolution of wastewater samples more difficult. Here we introduce a gold standard dataset constructed from synthetic viral control mixtures of known composition, spiked into a wastewater RNA matrix and sequenced on the Oxford Nanopore Technolog… Show more
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