A gold nanoflower based dual mode aptasensor for aflatoxin B1 detection using SERS and fluorescence effect simultaneously

Song, Zhiyi; Wang, Xinyi; Chen, Peifang; Wang, Zhouping; Ma, Xiaoyuan

doi:10.1016/j.saa.2023.122963

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…NBs bound with Raman active molecules have been used for their high SERS signal of the molecules on the NB surface. , Additionally, fluorecent dye-labeled NPs have been exploited for their advantage of as a sensitive optical technique for bioimaging. , Combining SERS and fluorescence highlights a scope attracting much more attention and great promise for biomedical applications, notably in diagnosis, imaging, and therapy . Prior research has incorporated both techniques using various types of nanoparticles, such as silica nanoparticles, spherical gold nanoparticles, gold nanoflowers, or gold nanostars. − However, the combination of SERS and fluorescence in the same nanomaterial system encounters an obstacle due to the need to reduce the quenching by maintaining a distance exceeding 10 nm between the fluorescent dye and the NP . Our research aims to design a NB complex employed for the dual function of SERS and fluorescence.…”

Section: Introductionmentioning

confidence: 99%

Gold–Silver Nanoboxes: A Systematic Investigation of Their SERS Capability and Dual Functions

Nguyen,

Tukova,

Tavakkoli Yaraki

et al. 2024

J. Phys. Chem. C

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Surface-enhanced Raman spectroscopy (SERS) is a nondestructive technique that provides ultrasensitive, highly specific molecular structure information for trace analysis and multicomponent profiling in biosensing applications. SERS utilizes the ability of plasmonic nanostructures to enhance the electric field around their surface. Gold−silver nanoboxes (NBs) hold the promise of superior SERS-related performance compared to conventional spherical nanoparticles in part because of their readily accessible "hotspot" corners. In this study, three types of NBs were synthesized using a one-pot method and then characterized using various analytical techniques, including ultraviolet−visible spectroscopy, electron microscopy, and Raman spectroscopy. Our studies, which involved SERS detection under three laser excitations at 532, 633, and 785 nm and finite-element method simulations, revealed that NBs with a size of 75 nm displayed the highest SERS performance, compared to other synthesized NBs and spherical gold and silver nanoparticles. When the 75 nm NBs were functionalized with an Raman active molecule and coated with a fluorescein isothiocyanate dye-integrated silica shell, the NBs can be analyzed using both fluorescence and SERS, which promises their potential for sensitive and specific biosensing applications in the future.

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