A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold

Tansık, Gülistan; Kilic, Erden; Beter, Mustafa; Demiralp, Bahtiyar; Sendur, Gullu Kiziltas; Can, Nuray; Özkan, Hüseyin; Ergül, Elif; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1039/c6bm00179c

Cited by 24 publications

(10 citation statements)

References 48 publications

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“…Mineralization of hard connective tissues such as bone and dentin is a complex process that involves deposition of hydroxyapatite within a collagenous matrix . Understanding the mechanisms of mineral deposition on collagen is vital for the development of treatments for mineralization‐related diseases, and may have key importance for the design of bioinspired materials for hard tissue repair .…”

Section: Introductionmentioning

confidence: 99%

Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization

Gülseren

Tansık

Garifullin

et al. 2018

Macromolecular Bioscience

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Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization, making it a prime candidate for the design of novel materials for bone and tooth regeneration. The bioactivity of DPP-derived proteins is controlled by the phosphorylation and dephosphorylation of the serine residues. Here an enzyme-responsive peptide nanofiber system inducing biomineralization is demonstrated. It closely emulates the structural and functional properties of DPP and facilitates apatite-like mineral deposition. The DPP-mimetic peptide molecules self-assemble through dephosphorylation by alkaline phosphatase (ALP), an enzyme participating in tooth and bone matrix mineralization. Nanofiber network formation is also induced through addition of calcium ions. The gelation process following nanofiber formation produces a mineralized extracellular matrix like material, where scaffold properties and phosphate groups promote mineralization. It is demonstrated that the DPP-mimetic peptide nanofiber networks can be used for apatite-like mineral deposition for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization

Gülseren

Tansık

Garifullin

et al. 2018

Macromolecular Bioscience

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“…5h–5l). 30 The treatment of bone tissue defects is a major challenge in orthopedics, and peptide materials that enhance osteogenesis can potentially replace the use of autograft and solve the risks of infections, donor site morbidity, and transplant rejections. 31…”

Section: Growth Factor Mimetic and Targeted Peptide Supramolecular Mamentioning

confidence: 99%

Peptide supramolecular materials for therapeutics

et al. 2018

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Supramolecular assembly of peptide-based monomers into nanostructures offers many promising applications in advanced therapies. In this Tutorial Review, we introduce molecular designs to control the structure and potential biological function of supramolecular assemblies. An emphasis is placed on peptide-based supramolecular nanostructures that are intentionally designed to signal cells, either directly through the incorporation of amino acid sequences that activate receptors or indirectly by recruiting native signals such as growth factors. Additionally, we describe the use and future potential of hierarchical structures, such as single molecules that assemble into nanoscale fibers which then align to form macroscopic strings; the strings can then serve as scaffolds for cell growth, proliferation, and differentiation.

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“…GAGs analogues, such as GAGs variants and GAGs mimics, are potential tools as they were designed to sequester and stabilize growth factors better and to overcome the drawbacks of native GAGs including their natural heterogeneity in structure, difficulty in modification, and uncertain biological roles ( Tansik et al, 2016 ). Quang Le et al (2021) synthesized an HS variant with high affinity toward BMP-2 named HS3 and constructed an HS3-functionalised scaffold integrated with collagen and bone granules with the aim to deliver BMP2 with sustained release.…”

Section: Proteoglycans Modulate the Chondrogenic Differentiation Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Chen

Sun

You

et al. 2021

Front. Cell Dev. Biol.

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Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.

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A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold

Cited by 24 publications

References 48 publications

Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization

Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization

Peptide supramolecular materials for therapeutics

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

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