A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics

Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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“…As a result, the combination of CDT and PTT represents an important research direction in cancer therapy. [ 83–106 ]…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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341

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“…Especially under laser irradiation, the HSN-enhanced heat could accelerate Fenton reaction to give birth to more ROS for inducing CDT, accompanied with HSN oxidation and decomposition into tiny fragments, intratumoral permeability augmentation, tumor recession and tumor metastasis repression. Similarly, Liu et al designed and synthesized ABTS-Fe/PVP (AFP) for enhancing PTA and CDT (F. Liu, Lin, et al, 2020). The design concept of AFP is based on the following principles that (a) ABTS is a substrate for horseradish peroxidase (HRP) and can be oxidized catalytically by HRP in the presence of H 2 O 2 to yield oxABTs, and Fe 3+ can oxidize ABTS directly into oxABTS in water; (b) the resulting oxABTs have strong light absorption in the NIR region; (c) Fe 3+ can trigger Fenton reaction to produce ROS for enhancing CDT and intracellular GSH removal also contributes to ROS production (Guan et al, 2020).…”

Section: Photothermal Ablation In Combination With Nanobiotechnologymentioning

confidence: 99%

Nanobiotechnology‐enabled energy utilization elevation for augmenting minimally‐invasive and noninvasive oncology thermal ablation

Zhang

Guo

Kong

et al. 2021

WIREs Nanomed Nanobiotechnol

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Depending on the local or targeted treatment, independence on tumor type and minimally‐invasive and noninvasive feature, various thermal ablation technologies have been established, but they still suffer from the intractable paradox between safety and efficacy. It has been extensively accepted that improving energy utilization efficiency is the primary means of decreasing thermal ablation power and shortening ablation time, which is beneficial for concurrently improving both treatment safety and treatment efficiency. Recent efforts have been made to receive a significant advance in various thermal methods including non‐invasive high‐intensity focused ultrasound, minimally‐invasive radiofrequency and microwave, and non‐invasive and minimally‐invasive photothermal ablation, and so on. Especially, various nanobiotechnologies and design methodologies were employed to elevate the energy utilization efficiency for acquiring unexpected ablation outcomes accompanied with tremendously reduced power and time. More significantly, some combined technologies, for example, chemotherapy, photodynamic therapy (PDT), gaseous therapy, sonodynamic therapy (SDT), immunotherapy, chemodynamic therapy (CDT), or catalytic nanomedicine, were used to assist these ablation means to repress or completely remove tumors. We discussed and summarized the ablation principles and energy transformation pathways of the four ablation means, and reviewed and commented the progress in this field including newly developed technology or new material types with a highlight on nanobiotechnology‐inspired design principles, and provided the deep insights into the existing problems and development direction. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…As previously mentioned, the decrease of intracellular GSH level is a promising method to address the limitation of CDT. In this regard, Liu and co‐colleagues developed facile preparation approaches to obtain 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid; ABTS)‐Fe and ABTS@MIL‐100 nanoreactors (Figure 4a) for H 2 O 2 and acid boosted PTT/CDT (F. Liu et al, 2020; F. Liu, Lin, et al, 2019). Considered as a substrate of horseradish peroxidase, ABTS was simply oxidized to oxABTS thereby featuring the function to eliminate GSH, further preserving ROS for facilitated CDT (Figure 4b,c).…”

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Yao

Fang

Yao

et al. 2020

WIREs Nanomed Nanobiotechnol

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Given the diversity, complexity, and heterogeneity of persistent tumors, traditional nanoscale monotherapeutic systems suffer from dissatisfactory curative efficiency with incidence of metastasis or relapse. In parallel, the trend of clinical research on the basis of nanomedicines has increasingly shifted from monotherapy toward combinatorial therapy for admirable synergetic performances. In this regard, cutting‐edge nanomedicines harnessing photothermal‐chemodynamic bimodal therapy (PTT/CDT) have opened up a highly‐efficient and relatively‐safe cancer theranostic paradigm. Still, the integration of PTT/CDT functional units into one nanomedicine remains a herculean but meaningful task to achieve notable super‐additive effects. This review aims to elucidate underlying synergistic interactions of PTT/CDT and highlight intriguing designs of nanomedicines for PTT/CDT including nanomaterial selection, performance optimization, multimodal therapy, visualization strategies, and targeting strategies. Furthermore, an outlook on further improvements of PTT/CDT is provided, emphasizing significant scientific issues that require remediation for clinical translation. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics

Abstract: A glutathione-depleting multifunctional chemodynamic therapy agent for tumor theranostics.

Cited by 35 publications

References 22 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Nanobiotechnology‐enabled energy utilization elevation for augmenting minimally‐invasive and noninvasive oncology thermal ablation

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

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