A glossary for reporting complications of treatment in gynecological cancers

Chassagne, D.; Sismondi, P; Horiot, J.C.; Sinistrero, G; Bey, P.; Zola, Paolo; Pernot, M.; Gerbaulet, A.; Kunkler, Ian; Michel, G

doi:10.1016/0167-8140(93)90260-f

Cited by 261 publications

(94 citation statements)

References 3 publications

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“…In 1993, Chassagne et al (17) published a glossary for reporting complications of treatment in gynecologic cancers to identify, score, and report early and late normal tissue damage regardless of treatment strategy. In 1995, the LENT-SOMA scales for each organ were published by the joint effort of two large organizations, the European Organization for Research and Treatment of Cancer and the Radiation Therapy Oncology Group.…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%

Rectal bleeding and its management after irradiation for uterine cervical cancer

Chun

Kang

Kil

et al. 2004

International Journal of Radiation Oncology*Biology*Physics

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Section: Incidence and Risk Factorsmentioning

confidence: 99%

Rectal bleeding and its management after irradiation for uterine cervical cancer

Chun

Kang

Kil

et al. 2004

International Journal of Radiation Oncology*Biology*Physics

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“…Changes in symptoms such as irregularity of bowel dysfunction, rectal blood loss or pain may be graded according to criteria stated in systems such as LENT SOMA and the FrancoItalian Glossary (Chassagne et al, 1993). The criteria for the grade of severity varies with the scoring system used, emphasising the need for a single universally agreed measure, but there are no described specific radiological features which define radiation proctitis (Capps et al, 1997).…”

mentioning

confidence: 99%

Systematic review for non-surgical interventions for the management of late radiation proctitis

et al. 2002

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Chronic radiation proctitis produces a range of clinical symptoms for which there is currently no recommended standard management. The aim of this review was to identify the various non-surgical treatment options for the management of late chronic radiation proctitis and evaluate the evidence for their efficacy. Synonyms for radiation therapy and for the spectrum of lower gastrointestinal radiation toxicity were combined in an extensive search strategy and applied to a range of databases. The included studies were those that involved interventions for the non-surgical management of late radiation proctitis. Sixtythree studies were identified that met the inclusion criteria, including six randomised controlled trials that described the effects of anti-inflammatory agents in combination, rectal steroids alone, rectal sucralfate, short chain fatty acid enemas and different types of thermal therapy. However, these studies could not be compared. If the management of late radiation proctitis is to become evidence based, then, in view of its episodic and variable nature, placebo controlled studies need to be conducted to clarify which therapeutic options should be recommended. From the current data, although certain interventions look promising and may be effective, one small or modest sized study, even if well-conducted, is insufficient to implement changes in practice. In order to increase recruitment to trials, a national register of cases with established late radiation toxicity would facilitate multi-centre trials with specific entry criteria, formal baseline and therapeutic assessments providing standardised outcome data.

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“…Following surgery, patients underwent brachytherapy to the vaginal vault using vaginal ovoids in a dose of 8 Gy at 0.5 cm from the applicator surface in two sittings. Surgical morbidity was classified according to the grading system of Chassagne et al [1] (Table 1). Early post-operative complication was defined as any adverse event occurring within 30 days from surgery.…”

Section: Methodsmentioning

confidence: 99%

The Role of Adjuvant Hysterectomy After Radiotherapy in Cervical Cancer

et al. 2014

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The aim of this study was to evaluate the morbidity and survival outcome following radical hysterectomy after chemoradiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stages IB-IIB cervical cancer patients in whom intracavitory brachytherapy was not feasible. We retrospectively reviewed the medical records of our patients who underwent adjuvant radical hysterectomy between January 2005 and December 2012. Post-operative complications were graded according to the grading system of Chassagne et al. (Radiother Oncol 26:195-202, 1993). Survival analysis was done using Kaplan-Meir method. Between January 2005 and December 2012, 43 patients underwent type 2 radical hysterectomy after external beam radiotherapy and concurrent chemotherapy. The median age of the study group was 44 years (range 28-63 years). There were no perioperative deaths. In the early post-operative period, there were 45 complications in 29 patients of which three were of grade 3 severity. The most common post operative complications were urinary tract infections and lymphoedema. The median follow-up time was 29 months (range 9-68 months). The 5-year overall survival was 85.5 % and disease-free survival 82.1 %. This study shows that radical hysterectomy is feasible with good survival outcome and acceptable morbidity after chemoradiotherapy in cervical cancer patients.

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A glossary for reporting complications of treatment in gynecological cancers

Cited by 261 publications

References 3 publications

Rectal bleeding and its management after irradiation for uterine cervical cancer

Rectal bleeding and its management after irradiation for uterine cervical cancer

Systematic review for non-surgical interventions for the management of late radiation proctitis

The Role of Adjuvant Hysterectomy After Radiotherapy in Cervical Cancer

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