A global perspective on risk factors for frailty in community-dwelling older adults: A systematic review and meta-analysis

Qin, Yuan; Hao, Xiaonan; Lv, Miaohua; Zhao, Xuetong; Wu, Shuang; Li, Kun

doi:10.1016/j.archger.2022.104844

Cited by 18 publications

(18 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Covariates were selected a priori based on their known association with frailty or medication burden [27][28][29]. The variables included age, sex, education level, duration of HIV infection, current tobacco and cannabis use, alcohol consumption, arthritis, polypharmacy (defined as the use of five or more non-HIV medications), cognitive performance measured using the Brief Cognitive Ability Measure (B-CAM) [15,30], severity of anxiety/depression symptoms measured using the respective subscales of the Hospital Anxiety and Depression Scale (HADS) [31], and Charlson Comorbidity Index (CCI) (frequently utilized as a measure of disease burden, and predicts mortality by categorizing and assigning weights to comorbid conditions) [32].…”

Section: Covariatesmentioning

confidence: 99%

The association between anticholinergic/sedative burden and physical frailty in people aging with HIV

Michael,

Brouillette,

Tamblyn

et al. 2023

Aids

View full text Add to dashboard Cite

Objective: This study aimed to estimate the strength of the association between anticholinergic/sedative burden and concurrent physical frailty in people aging with HIV. Design: This cross-sectional analysis examined baseline data from 824 adults with a mean age of 53 enrolled in the Positive Brain Health Now study. Methods: Anticholinergic medications were identified using four methods: Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Risk Scale (ARS), Anticholinergic Drug Scale (ADS), and the anticholinergic list of the Anticholinergic and Sedative Burden Catalog (ACSBC). Sedatives were identified using the Sedative Load Model (SLM) and the sedative list of the ACSBC. Physical frailty was assessed using a modified Fried Frailty Phenotype based on self-report items. Multivariable logistic regression models, adjusted for sociodemographic factors, lifestyle considerations, HIV-related variables, comorbidities, and co-medication use, were used to estimate odds ratios (ORs). Results: Anticholinergic burden demonstrated associations with frailty across various methods: total anticholinergic burden (OR range: 1.22–1.32; 95% CI range: 1.03–1.66), sedative burden (OR range: 1.18–1.24; 95% CI range: 1.02–1.45), high anticholinergic burden (OR range: 2.12–2.74; 95% CI range: 1.03–6.19), and high sedative burden (OR range: 1.94–2.18; 95% CI: 1.01–4.34). Conclusion: The anticholinergic and sedative burdens may represent modifiable risk factors for frailty in people aging with HIV. Future studies should evaluate the effects of reducing anticholinergic and sedative burdens on frailty outcomes and explore the prognostic value of diverse scoring methods.

show abstract

Section: Covariatesmentioning

confidence: 99%

The association between anticholinergic/sedative burden and physical frailty in people aging with HIV

Michael,

Brouillette,

Tamblyn

et al. 2023

Aids

View full text Add to dashboard Cite

show abstract

“…. A previous meta-analysis showed that female sex, single or widowed status, depression, diabetes, arthritis, urinary incontinence, chronic obstructive pulmonary disease, stroke, malnutrition, and history of falls were risk factors for frailty in older adults 27 . However, our metaanalysis showed that tooth loss increases the risk of frailty in subgroup analyses for country, not in subgroup analyses for age, type of study design, setting, and frailty assessment tools.…”

Section: Discussionmentioning

confidence: 99%

The association between the number of teeth and frailty among older adults: a systematic review and meta-analysis

Zhang,

Cao,

Teng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background As people age, tooth loss often accompanies the process of aging in the elderly. There were several studies to explore the association between the number of teeth and frailty among older people, with inconsistent results. We aimed to summarize the evidence for the association between tooth loss and frailty among older adults by using systematic review. Methods We systematically searched PubMed, Embase, and Ovid databases. Observational studies were included to examine the relationship between tooth loss and frailty in older adults. The Newcastle‒Ottawa scale was used to evaluate the studies’ quality. Results A total of 1454 articles were identified from the retrieved databases. We extracted 17 studies involving 24,897 participants for the final analysis. The pooled association between the number of teeth and frailty among older adults was 0.98 (Odd ratio, OR) (95% confidence interval [CI]: 0.97 − 0.99). In addition, older people with fewer than 20 teeth had a higher risk of frailty than those with more than 20 teeth, the pooled OR was 1.91 (95% CI: 1.48 − 2.47). Tooth loss increases the risk of frailty, regardless of age group, study design, setting, and frailty assessment tools (P<0.05). Conclusions Our study revealed a negative association between the number of teeth and frailty among older individuals. Furthermore, older people with fewer than 20 teeth faced a higher risk of frailty compared to those with more than 20 teeth.

show abstract

“…Covariates included age, gender, marital status, educational level, and monthly household income, as they have been identi ed as factors associated with both health literacy and frailty (34,35). Participants' age was recorded as a continuous variable, ranging from 70 to 84 years.…”

Section: Covariatesmentioning

confidence: 99%

The roles of health literacy and social support in the association between smartphone ownership and frailty in older adults: a moderated mediation model

Yi,

Yoon,

Won

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Understanding the role of smartphones to promote the health status of older adults is important in the digital society. Little is known about the effects of having smartphones on physical frailty despite its positive effect on the well-being of older adults. This study aimed to explore the association between smartphone ownership and frailty in community-dwelling older adults and its underlying mechanism. Methods We used data from the Korean Frailty and Aging Cohort Study and analyzed 2,469 older adults aged 72–86 years. Frailty, health literacy, and social support were assessed by Fried’s frailty phenotype, the Behavioral Risk Factor Surveillance System health literacy module, and the Enhancing Recovery in Coronary Heart Disease (ENRICHD) Social Support Instrument, respectively. The mediation model and moderated mediation model were estimated, where the mediator was health literacy and the moderator was social support, to explore the relationship between smartphone ownership and frailty. Results Of our study participants, 58.9% owned smartphones, and 10.9% were classified as frail. Smartphone ownership was negatively associated with frailty (β = −0.623, p < 0.001). Health literacy mediated the relationship between smartphone ownership and frailty (β = −0.154, boot confidence interval [CI] = − 0.222, − 0.096), and social support moderated the mediation effect (β = −0.010, Boot CI = − 0.016, − 0.004). Conclusions Owning smartphones among older adults could reduce the risk of frailty. Promoting health literacy and social support among older adults with smartphones would be effective to prevent frailty.

show abstract

A global perspective on risk factors for frailty in community-dwelling older adults: A systematic review and meta-analysis

Cited by 18 publications

References 93 publications

The association between anticholinergic/sedative burden and physical frailty in people aging with HIV

The association between anticholinergic/sedative burden and physical frailty in people aging with HIV

The association between the number of teeth and frailty among older adults: a systematic review and meta-analysis

The roles of health literacy and social support in the association between smartphone ownership and frailty in older adults: a moderated mediation model

Contact Info

Product

Resources

About