A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types
Aki Masuda,
Kazuhiko Nishida,
Rieko Ajima
et al.
Abstract:Understanding the genetic programs that drive neuronal diversification into classes and subclasses is key to understand nervous system development. All neurons can be classified into two types: commissural and ipsilateral, based on whether their axons cross the midline or not. However, the gene regulatory program underlying this binary division is poorly understood. We identified a pair of basic helix-loop-helix transcription factors, Nhlh1 and Nhlh2, as a global transcriptional mechanism that controls the lat… Show more
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