A global call to action to improve the care of people with fragility fractures

Dreinhöfer, Karsten; Mitchell, P. J.; Bégué, Thierry; Cooper, Cyrus; Costa, Matthew L.; Falaschi, P.; Hertz, Karen; Marsh, David; Maggi, Stefania; Nana, Arvind; Palm, Henrik; Speerin, Robyn; Magaziner, Jay

doi:10.1016/j.injury.2018.06.032

Cited by 105 publications

(86 citation statements)

References 6 publications

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“…Although causality for the secular trends cannot be established from observational data, the observed fracture trend may be related to the declining trend in osteoporosis-related prescriptions and DXA screening [8][9][10][11]. The alarming decline in the diagnosis and treatment of osteoporosis has been recognized as a crisis in the care of osteoporosis [18], and an urgent global call to action was initiated to define strategies to narrow the treatment gap and reduce the burden of osteoporotic fractures [19].…”

Section: Discussionmentioning

confidence: 99%

Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

et al. 2020

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This study expands on previous findings that hip fracture rates may no longer be declining. We found that age-and sex-adjusted fracture rates in the US plateaued or increased through mid-2017 in a population of commercially insured and Medicare Advantage health plan enrollees, in contrast to a decline from 2007 to 2013. Introduction The purpose of this study was to evaluate fracture trends in US commercial and Medicare Advantage health plan members aged ≥ 50 years between 2007 and 2017.

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Section: Discussionmentioning

confidence: 99%

Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

et al. 2020

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“…The FFN declared a Global Call to Action on fragility fractures to improve the care of people with fragility fractures. 8) There is an urgent need to improve: 1) acute multidisciplinary care for individuals with hip, clinical vertebral, or other major fragility fractures; 2) rapid secondary prevention to prevent future fractures after the first occurrence of fragility fracture in both younger and older individuals; 3) ongoing post-acute care for individuals with impaired functional capacities caused by hip and major fragility fractures. More than 80 leading organizations worldwide in the fields of medicine and nursing for older people have endorsed the Global Call to Action.…”

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confidence: 99%

Fragility Fracture Care: An Urgent Need to Implement the Integrated Model of Geriatric Care

Lim

2019

Ann Geriatr Med Res

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“…Fragility fracture generally occurs due to an injury that would be insufficient to cause fracture in a normal bone (1). It is a common disease in the elderly, leading to huge burdens on health and the economy, worldwide (2).…”

Section: Introductionmentioning

confidence: 99%

Beneficial role of microRNA‑328‑3p in fracture healing by enhancing osteoblastic viability through the PTEN/PI3K/AKT pathway

Wang

Zhang

2020

Exp Ther Med

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Although fragility fracture is a global public health burden, the mechanisms underlying fracture healing remain unclear. The present study aimed to assess the dynamic expression pattern of microRNA-328-3p (miR-328-3p) during fracture healing in patients with fragility fracture and to explore the functional role and mechanisms of miR-328-3p in the regulation of osteoblastic viability. The expression levels of miR-328-3p was examined using reverse transcription-quantitative PCR (RT-qPCR). Osteoblastic proliferation and apoptosis were analyzed via MTT and flow cytometry assays. A luciferase reporter assay was adopted to confirm the interaction between miR-328-3p and its target gene PTEN, and western blotting was used to explore the activity of PI3K/AKT signaling. The results of the present study demonstrated that serum miR-328-3p expression did not significantly differ at the early stage of healing in patients with fracture, but was markedly decreased 14 and 21 days post fixation (P<0.01). PTEN was demonstrated to be a target gene of miR-328-3p and was inhibited by miR-328-3p overexpression in osteoblasts (P<0.001). miR-328-3p overexpression increased osteoblastic proliferation but decreased apoptotic rate, with these effects being reversed by PTEN overexpression (P<0.05). The expression of phosphorylated-AKT was elevated in osteoblasts by miR-328-3p overexpression, but this effect was abolished by overexpressing PTEN. Thus, the present study revealed that miR-328-3p may accelerate fracture healing by promoting osteoblastic viability through the PTEN/PI3K/AKT pathway.

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A global call to action to improve the care of people with fragility fractures

Cited by 105 publications

References 6 publications

Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

Fragility Fracture Care: An Urgent Need to Implement the Integrated Model of Geriatric Care

Beneficial role of microRNA‑328‑3p in fracture healing by enhancing osteoblastic viability through the PTEN/PI3K/AKT pathway

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