A global bibliometric and visualized analysis in the status and trends of subchondral bone research

Mao, Xingjia; Chen, Chenglong; Wang, Bin; Hou, Jie; Chen, Xiang

doi:10.1097/md.0000000000020406

Cited by 24 publications

(29 citation statements)

References 35 publications

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“…We exported the retrieved data to Rstudio (version 3.6.2) and analysed using the bibliometrix package for annual scientific production over the year, most prolific authors, most relevant journals and occurrence keywords (49). VOSviewer software (version 1.6.14) was explored to visualise collaboration networks that exist among authors, institutions and countries that published the 100 most cited papers on African medicinal plant research (50).…”

Section: Data Analysis and Visualizationmentioning

confidence: 99%

Evaluation of 100 most cited research articles on African medicinal plants

Okaiyeto

Oguntibeju

2021

Plant Sci. Today

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The mission for drug discovery and progress has prompt researchers to scientifically validate the therapeutic uses of medicinal plants available worldwide, of which, African medicinal plants serve as a great reservoir. Despite the extensive work in the field of medicinal plants of African origin, however, bibliometric report on the work conducted on African medicinal plants is scarce, and hence, the present study aimed at evaluating the top 100 most cited articles on medicinal plant wealth of Africa. The literature data used for the bibliometric analysis was explored from Web of Science (WoS) while RStudio and VOSviewer software were used for data analysis and collaboration network visualization, respectively. The most prolific authors were Van Staden J, Jager AK, Teklehaymanot T whereas, the top 3 journals were Journal of Ethnopharmacology, Journal of Ethnobiology and Ethnomedicine, and South African Journal of Botany. Most cited journals were Journal of Ethnopharmacology, Phytochemistry, Phytotherapy Research. The topmost institutions in terms of the number of articles were the University of KwaZulu-Natal, University of Addis Ababa and Pretoria. South Africa was the most cited country followed by Nigeria. Single country publications dominated the field and therefore, multiple country collaboration should be a focus of social networks among the researchers in the field.

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Section: Data Analysis and Visualizationmentioning

confidence: 99%

Evaluation of 100 most cited research articles on African medicinal plants

Okaiyeto

Oguntibeju

2021

Plant Sci. Today

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“…The logistic growth model f( x ) = a/[1 + e b−cx ], where x is the year and f(x) represents the cumulative quantity of papers by year, was used to model the cumulative volume of documentation because of its great fitness and ability to predict future trends ( 154 ). VOS viewer (Leiden University, Leiden, Netherlands) were tools used to develop the co-occurrence analysis map ( 155 ).…”

Section: Global Status Of Mitochondrial and Osteoarthritis Researchmentioning

confidence: 99%

“…Variations in the quantity of academic publications in a certain research field are a significant indicator of the development trend ( 155 ). Determining the number of papers within a period of time and guiding multivariate statistical analysis are conducive to the research level and future trends ( 155 ). The global status of mitochondrial and osteoarthritis research has demonstrated that research on mitochondria and OA has been a popular topic in the field.…”

Section: Global Status Of Mitochondrial and Osteoarthritis Researchmentioning

confidence: 99%

“…The purpose of co-occurrence analysis is to determine the relevance of items according to the quantity of projects that appear together and describe the internal relationships and structure of an academic field, and reveal the research frontiers ( 156 ). The development of scientific research and programs could be monitored and followed closely as popular topics and directions were identified through co-occurrence analysis ( 155 , 157 ). Keywords were analyzed by VOS viewer, and 277 identified keywords are shown in Figure 6 .…”

Section: Global Status Of Mitochondrial and Osteoarthritis Researchmentioning

confidence: 99%

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Mitochondria: Potential Targets for Osteoarthritis

Mao

Wang

et al. 2020

Front. Med.

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Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by cartilage degeneration and narrow joint spaces. The role of mitochondrial dysfunction in promoting the development of OA has gained much attention. Targeting endogenous molecules to improve mitochondrial function is a potential treatment for OA. Moreover, research on exogenous drugs to improve mitochondrial function in OA based on endogenous molecular targets has been accomplished. In addition, stem cells and exosomes have been deeply researched in the context of cartilage regeneration, and these factors both reverse mitochondrial dysfunctions. Thus, we hypothesize that biomedical approaches will be applied to the treatment of OA. Furthermore, we have summarized the global status of mitochondria and osteoarthritis research in the past two decades, which will contribute to the research field and the development of novel treatment strategies for OA.

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“…With the rapid development of regenerative medicine, an increasing number of endogenous stem/progenitor cells, including synovium-derived MSCs, synovial fluid-derived MSCs, intraarticular fat pad-derived stem cells, and cartilagederived stem/progenitor cells, have been identified, applied, and targeted to repair cartilage injury [15][16][17]. However, few studies are available concerning the repair potential of stem/ progenitor cells originating from the native subchondral bone region [18]. Previous studies have shown the multipotency and self-renewal properties of SCB-SPCs [19,20].…”

Section: Introductionmentioning

confidence: 99%

Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell self-renewal by activating YAP/TAZ and facilitates cartilage repair in vivo

Zhao

Wang

et al. 2021

Stem Cell Res Ther

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Background Radial extracorporeal shockwave (r-ESW), an innovative and noninvasive technique, is gaining increasing attention in regenerative medicine due to its mechanobiological effects. Subchondral bone stem/progenitor cells (SCB-SPCs), originating from the pivotal zone of the osteochondral unit, have been shown to have multipotency and self-renewal properties. However, thus far, little information is available regarding the influences of r-ESW on the biological properties of SCB-SPCs and their therapeutic effects in tissue regeneration. Methods SCB-SPCs were isolated from human knee plateau osteochondral specimens and treated with gradient doses of r-ESW in a suspension stimulation system. The optimized parameters for SCB-SPC self-renewal were screened out by colony-forming unit fibroblast assay (CFU-F). Then, the effects of r-ESW on the proliferation, apoptosis, and multipotency of SCB-SPCs were evaluated. Moreover, the repair efficiency of radial shockwave-preconditioned SCB-SPCs was evaluated in vivo via an osteochondral defect model. Potential mechanisms were explored by western blotting, confocal laser scanning, and high-throughput sequencing. Results The CFU-F data indicate that r-ESW could augment the self-renewal of SCB-SPCs in a dose-dependent manner. The CCK-8 and flow cytometry results showed that the optimized shockwave markedly promoted SCB-SPC proliferation but had no significant influence on cell apoptosis. Radial shockwave exerted no significant influence on osteogenic capacity but strongly suppressed adipogenic ability in the current study. For chondrogenic potentiality, the treated SCB-SPCs were mildly enhanced, while the change was not significant. Importantly, the macroscopic scores and further histological analysis strongly demonstrated that the in vivo therapeutic effects of SCB-SPCs were markedly improved post r-ESW treatment. Further analysis showed that the cartilage-related markers collagen II and proteoglycan were expressed at higher levels compared to their counterpart group. Mechanistic studies suggested that r-ESW treatment strongly increased the expression of YAP and promoted YAP nuclear translocation in SCB-SPCs. More importantly, self-renewal was partially blocked by the YAP-specific inhibitor verteporfin. Moreover, the high-throughput sequencing data indicated that other self-renewal-associated pathways may also be involved in this process. Conclusion We found that r-ESW is capable of promoting the self-renewal of SCB-SPCs in vitro by targeting YAP activity and strengthening its repair efficiency in vivo, indicating promising application prospects.

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A global bibliometric and visualized analysis in the status and trends of subchondral bone research

Cited by 24 publications

References 35 publications

Evaluation of 100 most cited research articles on African medicinal plants

Evaluation of 100 most cited research articles on African medicinal plants

Mitochondria: Potential Targets for Osteoarthritis

Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell self-renewal by activating YAP/TAZ and facilitates cartilage repair in vivo

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