A Glimpse Into the Future of Transcatheter Interventional Heart Failure Therapies

Cerrud‐Rodriguez, Roberto; Burkhoff, Daniel; Latib, Azeem; Granada, Juan F.

doi:10.1016/j.jacbts.2021.09.012

Cited by 7 publications

(2 citation statements)

References 49 publications

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“…Simultaneously, the care of heart failure patients is increasingly overlapping with interventional cardiology and transcatheter interventional therapies. 7 Structural interventions are being used to address both acute and chronic heart failure in an aging and growing population of patients with advanced heart failure. As such, several major structural interventional cardiology trials such as COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation), MITRA-FR (Percutaneous Repair With the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation), and PARTNER 3 (Placement of Aortic Transcatheter Valves 3) have incorporated rehospitalizations end points into their primary composite outcomes.…”

Section: Readmissions In Structural Heart Disease Trialsmentioning

confidence: 99%

Trial End Points and Measures of Quality: Similar but Different

Nathan

Fiorilli

Giri

2022

Circ: Cardiovascular Interventions

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Recurrent heart failure hospitalizations have been used as a surrogate end point in clinical studies of heart failure for decades due to the associations of this end point with adverse long-term prognosis for the individual patient and increased costs to payers. 1,2 Given the strength of the association of recurrent heart failure hospitalizations and mortality as well as the inherent morbidity of admission for heart failure, recurrent heart failure hospitalizations have been commonly used as both a key component of primary composite end points for major heart failure clinical trials as well as a closely monitored individual secondary end points in the same studies.

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