A glance at…nutritional antioxidants and testosterone secretion

Glade, Michael J.; Smith, Kyl; Meguid, Michael M.

doi:10.1016/j.nut.2015.05.019

Cited by 22 publications

(23 citation statements)

References 60 publications

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“…Based on the pivotal roles of polyphenol on the suppression of MAO-B [32] and its role on penile erection via eNOS [33] together with the improved testicular functions [34] induced by polyphenol rich substance, we did suggest that the sexual enhancing effect of A. occidentale leaves extract might be associated with polyphenolic compounds content in the extract. However, this still required further investigation.…”

Section: Discussionmentioning

confidence: 99%

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Prabsattroo

Somsapt

Sritragool

et al. 2018

BioMed Research International

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In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. All doses of extract improved male sexual behaviors, suppressed MAO-B in NAc, enhanced TH-positive cells density in NAc, suppressed PDE-5 in penis, and enhanced interstitial cell of Leydig. The increase of serum testosterone, TH-positive cells density in VTA, eNOS expression in penis, and the decreased serum corticosterone were observed at some doses. Therefore, the sexual enhancing effect of extract occurred mainly via the improved dopaminergic and testicular functions. PDE-5 suppression in penis also played the role especially in the increased intromission behavior. Therefore, A. occidentale leaves extract is the potential protective agent against sexual dysfunction. However, further researches are necessary.

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Section: Discussionmentioning

confidence: 99%

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Prabsattroo

Somsapt

Sritragool

et al. 2018

BioMed Research International

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“…The mechanisms through which obesity affects male reproductive function are complex. Previous reports indicate that oxidative stress [11] and inflammatory responses [12][13][14] are associated with impaired function of Leydig cells. Furthermore, according to human [15] and animal studies [16], when oxidative stress and inflammatory responses in the semen of obese males are increased, the sperm motility is reduced, morphological defects are increased, and DNA damage and apoptotic rate of germ cells are increased [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice

Tang

Cao

et al. 2020

Oxidative Medicine and Cellular Longevity

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This study is aimed at investigating the effect of different exercise loads on the reproductive function of obese male mice and the underlying mechanisms. Male mice with high-fat diet-induced obesity were divided into obesity control (OC), obesity moderate-load exercise (OME), and obesity high-load exercise (OHE) groups. The OME and OHE groups were subjected to swimming exercise 5 days per week over a duration of 8 weeks, with the exercise load progressively increased to 2 h per day in the OME group and 2 h twice per day in the OHE group. In the OC group mice without exercise regimen, we observed a decrease in mRNA expression of antioxidant enzymes, increase in free radical products, upregulation of mRNA and protein expression of nuclear factor-κB and proinflammatory cytokines, inhibition of mRNA and protein expression of testosterone synthases, decrease in the serum testosterone level and sperm quality, and increase in sperm apoptosis. Although both moderate-load exercise and high-load exercise reduced body fat, only moderate-load exercise effectively alleviated obesity-induced oxidative stress, downregulated the expression of nuclear factor-κB and proinflammatory cytokines, and reversed the decrease in mRNA and protein expression of testosterone synthases, serum testosterone level, and sperm quality. These changes were not observed in the OHE group mice. Obesity-induced testicular oxidative stress and inflammatory response decreased testosterone synthesis and sperm quality. Moderate-load exercise alleviated the negative effect of obesity on male reproductive function by decreasing testicular oxidative stress and inflammatory responses. Although high-load exercise effectively reduced body fat, its effects on alleviating oxidative stress and improving male reproductive function were limited.

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“…Obesity is known to be characterised in an increase in the production of reactive oxygen species (ROS) and associated oxidative stress, both systemically [ 20 ] and within sperm themselves [ 21 ]. It is also well established that oxidative stress can impair sperm production and function [ 22 ], and there is evidence linking oxidative stress with impaired Leydig cell function [ 22 , 23 ]. Therefore testicular oxidative stress is also likely to play a significant role in obesity related male hypogonadism.…”

Section: Introductionmentioning

confidence: 99%

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men

Tremellen

2016

Basic Clin. Androl.

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Obesity is an increasing public health problem, with two-thirds of the adult population in many Western countries now being either overweight or obese. Male obesity is associated with late onset hypogonadism, a condition characterised by decreased serum testosterone, sperm quality plus diminished fertility and quality of life. In this paper we propose a novel theory underlying the development of obesity related hypogonadism- the GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function).Several observational studies have previously reported an association between obesity related hypogonadism (low testosterone) and systemic inflammation. However, for the first time we postulate that the trans-mucosal passage of bacterial lipopolysaccharide (LPS) from the gut lumen into the circulation is a key inflammatory trigger underlying male hypogonadism. Obesity and a high fat/high calorie diet are both reported to result in changes to gut bacteria and intestinal wall permeability, leading to the passage of bacterial endotoxin (lipopolysaccharide- LPS) from within the gut lumen into the circulation (metabolic endotoxaemia), where it initiates systemic inflammation. Endotoxin is known to reduce testosterone production by the testis, both by direct inhibition of Leydig cell steroidogenic pathways and indirectly by reducing pituitary LH drive, thereby also leading to a decline in sperm production.In this paper we also highlight the novel evolutionary benefits of the GELDING theory. Testosterone is known to be a powerful immune-suppressive, decreasing a man’s ability to fight infection. Therefore we postulate that the male reproductive axis has evolved the capacity to lower testosterone production during times of infection and resulting endotoxin exposure, decreasing the immunosuppressive influence of testosterone, in turn enhancing the ability to fight infection. While this response is adaptive in times of sepsis, it becomes maladaptive in the setting of “non-infectious” obesity related metabolic endotoxaemia.

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A glance at…nutritional antioxidants and testosterone secretion

Cited by 22 publications

References 60 publications

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men

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