A Glance at Methods for Cleft Palate Repair

Abstract

Context:Cleft palate is the second most common birth defect and is considered as a challenge for pediatric plastic surgeons. There is still a general lack of a standard protocol and patients often require multiple surgical interventions during their lifetime along with disappointing results.Evidence Acquisition:PubMed search was undertaken using search terms including 'cleft palate repair', 'palatal cleft closure', 'cleft palate + stem cells', 'cleft palate + plasma rich platelet', 'cleft palate + scaffold', 'palatal tissue engineering', and 'bone tissue engineering'. The found articles were included if they defined a therapeutic strategy and/or assessed a new technique.Results:We reported a summary of the key-points concerning cleft palate development, the genes involving this defect, current therapeutic strategies, recently novel aspects, and future advances in treatments for easy and fast understanding of the concepts, rather than a systematic review. In addition, the results were integrated with our recent experience.Conclusions:Tissue engineering may open a new window in cleft palate reconstruction. Stem cells and growth factors play key roles in this field.

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

“…This procedure is intended to add new bone between the jaw and the maxillary sinuses (in the caudal section of the maxillary sinus) [Sarkar and Lee, 2015]. Among the various techniques that are available to reconstruct deficient bone or fill a ridge, such as using a synthetic bone substitute like ceramics, bioglass, and glass ceramic compounds, autologous grafting is still a predictable and well-documented surgical approach [Tavakolinejad et al, 2014]. However, the major limiting factor for autogenous bone graft reconstruction is that the procedure is generally invasive and is associated with donor site complications, including infection, malformation, and pain [Sarkar and Lee, 2015].…”

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

“…The use of autogenous bone graft has many drawbacks related to morbidity at the donor site, and patients may present chronic pain at the site, paresthesia of the thigh, and hypertrophic scar. The loss of the graft due to local inflammation, bone resorption, and the development of oronasal fistulas is also frequently associated with unsuccessful repair (Borba et al, 2014;Tavakolinejad et al, 2014;Shafi et al, 2015).…”

The use of cellular technologies in the treatment of children with congenital cleft palate

“…5,6). Предвари-тельно с помощью бор-машины удаляли компакт-ную пластинку концевых отделов кости в области фрагментов альвеолярного отростка верхней че-люсти или в области небных отростков верхней челюсти.…”

“…Для лечения детей с врожденной патологией ЧЛО (врожденными расщелинами губы и неба) применяются МСК при проведении операций по закрытию изъянов твердого неба, а также при закрытии щелей альвеолярного отростка верх-ней челюсти в условиях ее врожденного недораз-вития [6]. Недостаток кости представляет собой проблему, с которой сталкивается врач если воз-никает необходимость восстановления зубного ряда или структур лица.…”