A Glance at… Broccoli, glucoraphanin, and sulforaphane

Glade, Michael J.; Meguid, Michael M.

doi:10.1016/j.nut.2015.03.003

Cited by 16 publications

(14 citation statements)

References 69 publications

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“…26 Glucoraphanin, a stable glucosinolate precursor of sulforaphane, is mainly derived from broccoli sprouts. 30,33 In both rodents and humans, glucoraphanin is hydrolyzed by gut microbiota-derived myrosinase into bioactive sulforaphane before intestinal absorption. 33 Importantly, emerging evidence has demonstrated the safety of orally administered glucoraphanin.…”

Section: Nrf2-keap1 Plays a Vital Role In Anti-obesitymentioning

confidence: 99%

“…30,33 In both rodents and humans, glucoraphanin is hydrolyzed by gut microbiota-derived myrosinase into bioactive sulforaphane before intestinal absorption. 33 Importantly, emerging evidence has demonstrated the safety of orally administered glucoraphanin. In one study, the administration of 69 µmol/day glucoraphanin for 60 days decreased plasma levels of liver function enzymes, including ALT, γ-GTP and alkali phosphatase activity, suggesting the liver dysfunction was ameliorated.…”

Section: Nrf2-keap1 Plays a Vital Role In Anti-obesitymentioning

confidence: 99%

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Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance

Nagata

Ota

2018

Adipocyte

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Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD). Particularly, obesity-induced metabolic endotoxemia plays an important role in the pathogenesis of insulin resistance and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of antioxidant signaling that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Pharmacological stimulation of Nrf2 mitigates obesity and insulin resistance in mice; however, Nrf2 activators are not clinically available due to biosafety concerns. A recent study demonstrated that glucoraphanin, a precursor of the Nrf2 activator sulforaphane, ameliorates obesity by enhancing energy expenditure and browning of white adipose tissue, and attenuates obesity-related inflammation and insulin resistance by polarizing M2 macrophages and reducing metabolic endotoxemia. Thus, this review focuses on the efficiency and safety of glucoraphanin in alleviating obesity, insulin resistance, and NAFLD. Abbreviations: ALT, Alanine aminotransferase; AMPK, AMP-activated protein kinase; ATMs, Adipose tissue macrophages; BAT, Brown adipose tissue; CDDO-Im, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid-imidazolide; CDDO-Me, CDDO-methyl ester; DIO, High-fat-diet-induced obese; FFA, Free fatty acid; FGF, Fibroblast growth factor; GTP, Glutamyl transpeptidase; HFD, High-fat diet; IKKβ, Inhibitor of κB-kinase β; IL, Interleukin; JNK, C-Jun N-terminal kinase; KD, Knockdown; Keap1, Kelch-like ECH-associated protein 1; KO, Knockout; LPS, Lipopolysaccharide; NADPH, Nicotinamide adenine dinucleotide phosphate; NAFLD, Non-alcoholic fatty liver disease; NF-κB, Nuclear factor-κB; Nrf2, Nuclear factor E2-related factor 2; ROS, Reactive oxygen species; T2D, Type 2 diabetes; TLR, Toll-like receptor; TNF, tumor necrosis factor; UCP, Uncoupling protein; WAT, White adipose tissue.

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Section: Nrf2-keap1 Plays a Vital Role In Anti-obesitymentioning

confidence: 99%

Section: Nrf2-keap1 Plays a Vital Role In Anti-obesitymentioning

confidence: 99%

Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance

Nagata

Ota

2018

Adipocyte

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“…Broccoli is a vegetable of the Brassicaceae (or Cruciferae) family, which contain sulfur-based compounds named glucosinolates [181]. These compounds are hydrolyzed to biologically active isothiocyanates (ITC) by the action of myrosinase, a vegetable enzyme present in the human gut microbiota [182,183]. Glucoraphanin, the predominant glucosinolate in broccoli, releases the ITC sulforaphane (SFN) [184].…”

Section: Available Evidencementioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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“…Recent studies report that sulforaphane is safe and tolerable and exhibits its benefi cial effects by activating liver phase II detoxifi cation enzymes. Sulforaphane is considered as a potent fi ghter against oxidative stress with its antioxidant, anti-infl ammatory and anti-tumor effects (13,14). In this study, we intended to investigate whether sulforaphane is protective against acetaminopheninduced liver damage or not, by evaluating the levels of neopterin, a cellular immunosystem activation marker, as well as CRP, lipid peroxidation and glutathione levels.…”

Section: Introductionmentioning

confidence: 99%

The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene

Dokumacıoğlu¹,

İskender²,

Aktaş³

et al. 2017

BLL

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OBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and infl ammation in rats liver with toxic hepatitis induced by acetaminophene. BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 μg/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 μg/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were signifi cantly increased compared to control group. GSH level of group APAP was signifi cantly lower than in the control group. CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51). Text in PDF www.elis.sk.

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A Glance at… Broccoli, glucoraphanin, and sulforaphane

Cited by 16 publications

References 69 publications

Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance

Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance

A Critical Review on the Role of Food and Nutrition in the Energy Balance

The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene

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