A giant mediastinal thymolipoma: a rare pathological entity

Sharma, Kailash Chand; Bhakuni, Yogendra Singh; Darlong, Laleng M; Pasricha, Sunil; Dewan, Ajay Kumar; Chand, Rashika; Goswami, Pranay; Rajappa, Suhas Kodasoge

doi:10.1007/s12055-018-0700-9

“…Thymolipomas are characterized by the presence of abundant mature fat, which separates the thymic tissue component, with no evidence of atypia or mitotic activity. Although most of these tumors are clinically quiescent, they can grow to significant sizes and present clinical symptoms such as compression of the lower respiratory tree, resulting in breathlessness, coughing, chest discomfort, and upper respiratory tract infection 2 . Furthermore, it can lead to cardiac compression and subsequently, chronic heart failure 4 .…”

Section: Discussionmentioning

confidence: 99%

“…1 With a slow growth pattern, these tumors are commonly identified when they generate symptoms of pressure or are incidentally detected during the assessment of other complaints. 2 Conditions such as chronic lymphocytic leukemia, myasthenia gravis, aplastic anemia, hyperthyroidism, and Hodgkin's disease have been found to be associated with this tumor. Complete surgical excision remains the preferred choice for treatment.…”

Section: Introductionmentioning

confidence: 99%

A rare case of giant mediastinal thymolipoma in an 18‐year man

Soleimani,

Aminzadeh,

Hassannejad

et al. 2024

Clinical Case Reports

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“…No cyclin-dependent kinase (CDK) 4 expression is evident in adipocytes, while cluster of differentiation (CD)1a, CD99, and terminal deoxynucleotid transferase (TdT) are highlighting the thymic lymphoid (immature) cells (Figures 5 and 6 ). Additionally, immunostaining for pan-cytokeratin (CK) AE1/AE3 and p63 or CK5/6, as immunomarkers of squamous differentiation, are positive in the normal thymic epithelium (Figures 7 , 8 , 9 , 10 ) [ 3 ]. If striated myoid cells are added in the cellular population of thymolipomas, they show myoglobin and desmin positivity, although they are negative for alpha-smooth muscle actin ( α -SMA) [ 65 ].…”

Section: ⧉ Thymolipoma Morphologymentioning

confidence: 99%

Thymolipoma – the frontier between hamartoma and neoplasia?

Amălinei

¹

,

Grigoraș²,

Bălan³

et al. 2021

Rom J Morphol Embryol

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Thymolipoma is an uncommon benign thymus lesion, with a partially deciphered etiopathogeny, being most frequently diagnosed in young patients, regardless of gender. Incidentally diagnosed in asymptomatic patients, larger thymolipomas lead to symptoms related to neighboring mediastinal structures compression, with an intensity which is correlated with the mass size. Our review presents the main epidemiological, pathogenic, clinicopathological and morphological characteristics of this rare pathology. Sometimes, thymolipomas may be associated with paraneoplastic syndromes, which are alleviated by the mass complete surgical resection. Imagistics may orientate the diagnosis, which is certified by the microscopic examination of the resection specimens. Extensive thymectomy remains the current therapeutic option and new tools have been developed to increase the accuracy of the surgical procedure to avoid incidental lesions of the important elements of the anterior mediastinum. Although rare, thymolipomas should be considered in the differential diagnosis of mediastinal masses and of paraneoplastic syndromes.

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“…No cyclin-dependent kinase (CDK) 4 expression is evident in adipocytes, while cluster of differentiation (CD)1a, CD99, and terminal deoxynucleotid transferase (TdT) are highlighting the thymic lymphoid (immature) cells (Figures 5 and 6). Additionally, immunostaining for pan-cytokeratin (CK) AE1/AE3 and p63 or CK5/6, as immunomarkers of squamous differentiation, are positive in the normal thymic epithelium (Figures 7-10) [3]. If striated myoid cells are added in the cellular population of thymolipomas, they show myoglobin and desmin positivity, although they are negative for alphasmooth muscle actin (α-SMA) [65].…”

Section: Figure 4 -Thymolipoma Spectrum; Added To Common Type Of Thym...mentioning

confidence: 99%

“…Thymolipomas are relatively rare tumors, representing about 2-9% of thymic neoplasms [1][2][3][4] and show a slow development. They have been firstly described in literature by Lange, in 1916, and named "lipoma of the thymusˮ [5].…”

Section:  Introductionmentioning

confidence: 99%

Untitled

2021

Rom J Morphol Embryol

0

View full text Add to dashboard Cite

Thymolipoma is an uncommon benign thymus lesion, with a partially deciphered etiopathogeny, being most frequently diagnosed in young patients, regardless of gender. Incidentally diagnosed in asymptomatic patients, larger thymolipomas lead to symptoms related to neighboring mediastinal structures compression, with an intensity which is correlated with the mass size. Our review presents the main epidemiological, pathogenic, clinicopathological and morphological characteristics of this rare pathology. Sometimes, thymolipomas may be associated with paraneoplastic syndromes, which are alleviated by the mass complete surgical resection. Imagistics may orientate the diagnosis, which is certified by the microscopic examination of the resection specimens. Extensive thymectomy remains the current therapeutic option and new tools have been developed to increase the accuracy of the surgical procedure to avoid incidental lesions of the important elements of the anterior mediastinum. Although rare, thymolipomas should be considered in the differential diagnosis of mediastinal masses and of paraneoplastic syndromes.

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A giant mediastinal thymolipoma: a rare pathological entity

Cited by 5 publications

References 3 publications

A rare case of giant mediastinal thymolipoma in an 18‐year man

A rare case of giant mediastinal thymolipoma in an 18‐year man

Thymolipoma – the frontier between hamartoma and neoplasia?

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