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Pancreatic metastases are commonly solitary solid lesions frequently derived from primary renal cell carcinoma, lung cancer, or melanoma. Very few case reports have described cystic-appearing metastases in the pancreas and even fewer have reported a combination of cystic and solid metastatic lesions. Synovial sarcoma is a rare and aggressive soft tissue neoplasm, frequently metastasizing to the lungs and bones. We present a case of primary synovial sarcoma with multiple solid and cystic-appearing pancreatic metastases diagnosed by endoscopic ultrasound and sonographically guided fine-needle aspiration.
Pancreatic metastases are commonly solitary solid lesions frequently derived from primary renal cell carcinoma, lung cancer, or melanoma. Very few case reports have described cystic-appearing metastases in the pancreas and even fewer have reported a combination of cystic and solid metastatic lesions. Synovial sarcoma is a rare and aggressive soft tissue neoplasm, frequently metastasizing to the lungs and bones. We present a case of primary synovial sarcoma with multiple solid and cystic-appearing pancreatic metastases diagnosed by endoscopic ultrasound and sonographically guided fine-needle aspiration.
Pisters and Patel [1] presented an excellent review on the management of gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Extra-GISTs, which arise from outside the GI tract but histologically resemble their GI counterparts, have been only scatteredly reported in literatures. Pancreatic GIST is a rare neoplasm with prognosis and biological behavior unknown. Here, we presented the management and outcome of a case with pancreatic malignant GIST. Furthermore, other cases reported in English literature were reviewed, with clinical characteristics, prognosis, and predictors for adverse outcomes analyzed.A 55-year-old man was found to have a large epigastric cystic lesion during check-up for abdominal discomfort. Laboratory and radiological examinations revealed a suspected pancreatic pseudocyst or cystic tumor. Distal pancreatectomy plus splenectomy was performed for this large lesion that arised from pancreatic body and tail. Pancreatic malignant GIST was diagnosed by histopathology and immunohistochemistry with positive staining for CD117 and CD34 [2]. He was treated with imatinib (400 mg orally once daily) after surgery for nearly 2 years and followed-up with 3-6 monthly CT scans. He did well until 6 months after drug withdrawal, when CT scan showed two low-density masses measuring 6 cm  6 cm and 2.5 cm  3 cm located in the left epigastric region. He received relaparotomy, and curative resection was performed for the tumors, which were confirmed recurrence and intraperitoneal metastasis of GIST by histopathology and immunohistochemistry. The patient continued taking imatinib and remained disease-free for 17 months after surgery.To date, only 12 cases have been reported (including our case) in the English literature [2][3][4][5][6][7]. The clinicopathologic features of these patients are listed in Table I. The majority have been diagnosed in patients older than 40 years (10/12), and the mean age at diagnosis is 54.1, with a male/female ratio of 1:2. Major clinical presentations included abdominal pain or discomfort, weight loss, and fatigue, however, one-third of them were incidental found during a routine workup. One patient presented with a 4-year history of increasingly hemorrhagic pancreatic cyst [3]. None of the patients had obstructive jaundice or history of trauma. The tumor could occur in any part of the pancreas with slightly more frequent in the body and tail. CT scan usually showed large cystic mass (in eight cases larger than 10 cm) with a few solid components. Tumor markers including CA19-9 and CEA were not elevated. The rate of pre-operative misdiagnosis was rather high.Follow-up ranging from 1 to 60 months were mentioned for 10 patients, all underwent surgical resection. Among them, four received adjuvant post-surgical therapy with imatinib. During the follow-up period, all 10 patients were still alive, however, recurrence and metastasis (liver, retroperitoneal nodal, or intra-abdominal) developed in three cases 1 month, 9 month...
A 79-year-old male was referred to the hospital with a history of abdominal discomfort. Abdominal computed tomography revealed a cystic tumor with irregular wall thickness, approximately 50 mm in diameter, along the lesser curvature of the gastric body. Magnetic resonance imaging visualized the mass as signal-hyperintense on T2-weighted imaging. Esophagogastroduodenoscopy showed a submucosal tumor with normal mucosa. Surgery was performed and the 60 × 50 × 50 mm mass was resected. The resected tumor comprised cystic and solid regions; the cystic region was filled by light bloody serous fluid. On histological examination, a solid region of the resected tumor showed a spindle-cell appearance. The diagnosis was gastric gastrointestinal stromal tumor (GIST) with predominant cystic formation. GISTs are usually solitary tumors, but in this case the tumor demonstrated extremely predominant cystic formation. Lesions with a hemorrhage or necrosis may form large cystic spaces. GISTs may show extensive cystic changes in response to tyrosine kinase inhibitor treatment; however, this patient had not undergone any such treatment before diagnosis. This represents an interesting case of a gastric GIST with predominant cystic formation occupying most of the tumor volume. Care should be taken to differentiate between GISTs and actual intra-abdominal cystic lesions.
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