A Giant Calcifying Pseudocyst Seen in a Patient with Overlap Syndrome

Hashiro, Makoto; Maeda, Masayuki; Kobayashi, Yoichi; Yoshikawa, Kunihiko

doi:10.1111/j.1346-8138.1989.tb01237.x

Cited by 6 publications

(5 citation statements)

References 5 publications

(6 reference statements)

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“…Multiple areas of ossification supported the longstanding nature of the pathologic process. Although a giant calcified pseudocyst has been reported in a patient with overlap syndrome (12), to the best of our knowledge, such a massive dystrophic calcification in a true epidermal cyst has not been described in dermatomyositis or other connective tissue disorders.…”

Section: Discussionmentioning

confidence: 88%

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

et al. 2006

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Background: Mechanisms governing the normal resolution processes of inflammation are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of chronic inflammation. The removal of apoptotic cell material and their potentially histotoxic contents is a prerequisite of resolution. Engulfment by macrophages is an important disposal route, and changes in the apoptotic cells that are associated with their recognition by macrophages are the subject of this report. Methods: Apoptosis and necrosis in primary cells and cell lines were induced by various stimuli. The binding profile of 23 different lectins for vital, apoptotic, and necrotic cells were analyzed by flow cytometry. Results: We observed that lectins were able to attach to the cell surfaces of vital and dying cells. Some lectins exhibited membrane destructive properties and, consecutively, changed the morphology of the cells as detected by flow cytometry. Other lectins did not show differences in their binding to viable and apoptotic cells. Those lectins were, therefore, not used for analyses of surface changes. The lectins Griffonia

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Section: Discussionmentioning

confidence: 88%

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

et al. 2006

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“…Cases presenting all three major CTD (dcSSc, DM/PM, and SLE) are extremely rare, and only four case reports have been reported (Table 1). 3–6 Among five cases, three were Japanese. The ages ranged 16–58 years, and four of the five cases were female.…”

Section: Discussionmentioning

confidence: 99%

“…(Table 1). [3][4][5][6] Among five cases, three were Japanese. The ages ranged 16-58 years, and four of the five cases were female.…”

Section: Discussionmentioning

confidence: 99%

“…Having more than one other CTD with SSc is relatively rare, and the prevalence has been reported to be 3.9% 2 . In particular, only a few cases of the three major overlapping CTD, SSc, polymyositis/dermatomyositis (PM/DM), and systemic lupus erythematosus (SLE), have been reported 3–6 …”

Section: Introductionmentioning

confidence: 99%

“…2 In particular, only a few cases of the three major overlapping CTD, SSc, polymyositis/dermatomyositis (PM/DM), and systemic lupus erythematosus (SLE), have been reported. [3][4][5][6] An antibody against the PM/Scl complex, recently proven to be a human exosome protein, is found in patients with SSc/PM OS. 7 Patients with anti-PM/Scl antibodies have been reported to be milder in severity and respond to moderate immunosuppression with good prognosis.…”

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confidence: 99%

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Anti‐polymyositis/Scl antibody‐positive overlap syndrome of diffuse cutaneous systemic sclerosis, dermatomyositis, systemic lupus erythematosus, and antiphospholipid syndrome

Saito

Endo

Nishio

et al. 2021

The Journal of Dermatology

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A 37‐year‐old Japanese man with a 3‐year history of diffuse cutaneous systemic sclerosis was admitted to our hospital with high fever, arthralgia, myalgia, and muscle weakness. A physical examination revealed facial erythema, Gottron’s sign, and mechanic’s hands in addition to skin sclerosis. Laboratory data revealed significantly elevated levels of creatine kinase and decreased complement. Anti‐RNP, anti‐Smith, anti‐DNA, anti‐β2‐glycoprotein 1, anti‐polymyositis (PM)/Scl75, and anti‐PM/Scl100 antibodies were detected. He also had urinary protein, interstitial lung disease, pericarditis, multifocal cerebral infarctions, and leukoencephalopathy. Thus, a diagnosis of overlap syndrome of diffuse cutaneous systemic sclerosis, dermatomyositis, and systemic lupus erythematosus with antiphospholipid syndrome was made. Because of the intractable course, he was treated with multiple immunosuppressive and immunomodulatory drugs, including three rounds of 1000 mg methylprednisolone pulse therapy. This is the first case report of anti‐PM/Scl antibody‐positive overlap syndrome of three major connective tissue diseases.

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Large Subcutaneous Calcification in Systemic Lupus Erythematosus

Nomura

Okada²,

Okada³

et al. 1990

Arch Dermatol

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A 42-year-old woman first received the diagnosis of systemic lupus erythematosus at our hospital in 1986. Thereafter, she noticed a small subcutaneous nodule on her left leg. This nodule became larger, and many new nodules appeared. Some of these were amassed to form large, flat, platelike tumors. Roentgenographic and histological examination revealed that they were calcium deposits. To our knowledge, this is the first report of very large, hard tumors resulting from calcium deposition in the skin.

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A Giant Calcifying Pseudocyst Seen in a Patient with Overlap Syndrome

Cited by 6 publications

References 5 publications

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

Anti‐polymyositis/Scl antibody‐positive overlap syndrome of diffuse cutaneous systemic sclerosis, dermatomyositis, systemic lupus erythematosus, and antiphospholipid syndrome

Large Subcutaneous Calcification in Systemic Lupus Erythematosus

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