A giant aggressive angiomyxoma of vulva in a young woman

Abstract

Rationale:Aggressive angiomyxoma (AAM) is a rare and benign invasive mesenchymal stromal tumor predominantly in women at reproductive age. AAM tends to relapse locally and should be differentially diagnosed from other mesenchymal tumors.Patient concerns:We report here a rare case of massive vulvar AAM in a 22-year-old Chinese woman with left labia majora mass with ulcer.Diagnoses:The diagnosis “aggressive angiomyxoma of vulva” was based on clinicopathologic and immunohistochemical features.Interventions:A surgery with local excision of the mass was performed.Outcomes:The patient was discharged 12 days after the surgery. There was no AAM recurrence or metastasis in a period of 12-month follow-up.Lessons:The vulvar AAM is a benign and aggressive mesenchymal tumor. In this case, we present the diagnosis, treatment, and prognosis for vulvar AAM. The tumor was removed completely by the surgery, but a long-term follow-up is requisite for surveilling on recurrence.

Case report and literature review: Rare male aggressive angiomyxoma of the scrotum

“…Immunohistochemical staining plays a crucial role in the diagnosis of AAM, although there is no specific immunohistochemical marker of AAM. The neoplastic cells of AAM are generally positive for desmin, vimentin, SMA, CD34, ER, and PR but negative for S-100 and CK in female patients ( 47 ). Previous studies have shown that ER and PR stains are generally negative in males with AAM compared with females ( 37 ).…”

Symptomatic vulvar mucinous cyst: A case report and review of the literature

“…The location was not that of a typical vulvar cyst, being too anterior for a Bartholin gland cyst, too lateral and posterior for a Skene gland cyst, and too lateral for a vestibular mucinous cyst [2]. It did not have the discoloration of a hemangioma, was too fluctuant to be a lipoma, and was not pedunculated like a giant angiomyxoma or giant fibroepithelial polyp of the vulva [4,5].…”