A genotype and phenotype database of genetically modified malaria-parasites

Janse, Chris J.; Kroeze, Hans; Wigcheren, Auke van; Mededovic, Senad; Fonager, Jannik; Franke-Fayard, Blandine; Waters, Andrew P.; Khan, Shahid M.

doi:10.1016/j.pt.2010.06.016

Cited by 54 publications

(51 citation statements)

References 51 publications

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“…This landmark discovery marked the beginning of the widespread use of murine malaria parasites as in vivo models for biomedical malaria research. These model systems became invaluable tools for large-scale drug testing, experimental vaccine development, and molecular and cellular studies of malaria-associated pathology and host immune responses (22,23). The importance of these murine hosts is such that the complete genome of one of them, P. yoelii, was sequenced in parallel with that of P. falciparum (13).…”

Section: Discussionmentioning

confidence: 99%

High diversity of West African bat malaria parasites and a tight link with rodentPlasmodiumtaxa

Schaer

Perkins

Decher

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

116

147

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As the only volant mammals, bats are captivating for their high taxonomic diversity, for their vital roles in ecosystems-particularly as pollinators and insectivores-and, more recently, for their important roles in the maintenance and transmission of zoonotic viral diseases. Genome sequences have identified evidence for a striking expansion of and positive selection in gene families associated with immunity. Bats have also been known to be hosts of malaria parasites for over a century, and as hosts, they possess perhaps the most phylogenetically diverse set of hemosporidian genera and species. To provide a molecular framework for the study of these parasites, we surveyed bats in three remote areas of the Upper Guinean forest ecosystem. We detected four distinct genera of hemosporidian parasites: Plasmodium, Polychromophilus, Nycteria, and Hepatocystis. Intriguingly, the two species of Plasmodium in bats fall within the clade of rodent malaria parasites, indicative of multiple host switches across mammalian orders. We show that Nycteria species form a very distinct phylogenetic group and that Hepatocystis parasites display an unusually high diversity and prevalence in epauletted fruit bats. The diversity and high prevalence of novel lineages of chiropteran hemosporidians underscore the exceptional position of bats among all other mammalian hosts of hemosporidian parasites and support hypotheses of pathogen tolerance consistent with the exceptional immunology of bats.Haemosporida | Chiroptera | vector-borne disease | molecular phylogeny | host-pathogen coevolution

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Section: Discussionmentioning

confidence: 99%

High diversity of West African bat malaria parasites and a tight link with rodentPlasmodiumtaxa

Schaer

Perkins

Decher

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

116

147

View full text Add to dashboard Cite

show abstract

“…In P. falciparum, RAP3 is not essential for merozoite invasion, most likely because RAP2 can complement the loss of RAP3 [70]. In P. berghei which only has a single RAP2/3 gene, successful knockout of RAP2/3 has not been achieved [71]. This suggests that the RAP complex may indeed be crucial for parasite survival in an in vivo setting.…”

Section: Rhoptry Bulb Proteins Function Predominantly Downstream Of Imentioning

confidence: 99%

Plasmodium rhoptry proteins: why order is important

Counihan

Kalanon

Coppel

et al. 2013

Trends in Parasitology

101

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“…Kooij). any species of Plasmodium [2]. Crucially, the complete life cycle can be studied in vivo, allowing for a truly systematic and eventually genome-wide scale endeavour.…”

Section: Introductionmentioning

confidence: 99%