“…Activated by a plasminogen activator, plasminogen produces a highly e cient serine protease that can hydrolyze brin and various ECM components. Numerous invasive pathogens can capture plasminogen and bind to plasminogen receptors (PlgRs) on their surfaces, activating the brinolytic system, degrading the ECM system, and facilitating its adhesion and colonization, leading to tissue dissemination [18,30,46]. Examples include LppA and LppB in Mycoplasma bovis and GAPDH and enolase in Mycoplasma hyorhinis, which act as PlgRs to bind and activate plasminogen, enabling the pathogen to degrade the host ECM [28, 30,47,48].…”