A Genome-Wide Scan for Loci Affecting Normal Adult Height in the Framingham Heart Study

Mukhopadhyay, Nandita; Finegold, David N.; Larson, Martin G.; Cupples, L. Adrienne; Myers, Richard H.; Weeks, Daniel E.

doi:10.1159/000073203

Cited by 25 publications

(22 citation statements)

References 35 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have identified major loci for height on chromosomes 15, 8 and 3, and a locus for BMI on chromosome 4. We did not detect a significant linear correlation between height and age, although other studies have shown an inverse relationship with age (Mukhopadhyay et al 2003). Since we used self-reported height, participants in our study may be reporting a height measurement recalled from an age period different to their current height.…”

Section: Discussioncontrasting

confidence: 65%

“…Previous studies have frequently reported heritability estimates in excess of 0.6 for height (e.g., Hirschhorn et al 2001;Perola et al 2001;Deng et al 2002;Wiltshire et al 2002;Xu et al 2002;Mukhopadhyay et al 2003;Wu et al 2003). In African Americans, heritability estimates have been reported to be as high as 0.87 (Luke et al 2001), and the multi-ethnic range of heritability reported by Wu et al (2003) of 0.75-0.98 included an African American sample.…”

Section: Discussionmentioning

confidence: 99%

“…Segregation analyses have suggested that the observed variation may be due to at least one major recessive gene (Xu et al 2002) that could account for 37-53% of the variance for both height and weight (Ginsburg et al 1998), with a significant polygenic background (Xu et al 2002). Recent studies have reported the heritability for height in the range 0.69-0.98 (Hirschhorn et al 2001;Perola et al 2001;Deng et al 2002;Wiltshire et al 2002;Xu et al 2002;Mukhopadhyay et al 2003;Wu et al 2003). Quantative trait loci (QTLs) for height have been reported in studies of six populations of European ancestry (Hirschhorn et al 2001;Perola et al 2001;Deng et al 2002;Wiltshire et al 2002;Xu et al 2002;Mukhopadhyay et al 2003), one study of Pima Indians (Thompson et al 1995) and one multi-ethnic American study (Wu et al 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Major loci from these eight studies have been reported on several different chromosomes. Using the following criteria to define a replicated locus: the same unstratified phenotype, reported pointwise p-values <0.05 from genome scans in at least two populations, and linkage peaks within 25 cM of each other, replication has been observed for loci at 6q24-27 (Hirschhorn et al 2001;Xu et al 2002;Mukhopadhyay et al 2003), 7q31 (Hirschhorn et al 2001;Perola et al 2001;Wu et al 2003), and 12q1 (Hirschhorn et al 2001;Xu et al 2002). A number of other loci have been reported in the literature as replicating previous loci, although they do not meet these criteria, including: 2p12 (Hirschhorn et al 2001;Wu et al 2003); 9p1 (Hirschhorn et al 2001;Xu et al 2002); 18q21-11 (Hirschhorn et al 2001;Mukhopadhyay et al 2003); and 20p11 (Thompson et al 1995;Wu et al 2003).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Loci Contributing to Adult Height and Body Mass Index in African American Families Ascertained for Type 2 Diabetes

Sale

Freedman²,

Hicks

et al. 2005

Annals of Human Genetics

View full text Add to dashboard Cite

SummaryHeight and body mass index (BMI) have high heritability in most studies. High BMI and reduced height are well-recognized as important risk factors for a number of cardiovascular diseases. We investigated these phenotypes in African American families originally ascertained for studies of linkage with type 2 diabetes using self-reported height and weight. We conducted a genome wide scan in 221 families containing 580 individuals and 672 relative pairs of African American descent. Estimates of heritability and support for linkage were assessed by genetic variance component analyses using SOLAR software. The estimated heritabilities for height and BMI were 0.43 and 0.64, respectively. We have identified major loci contributing to variation in height on chromosomes 15 (LOD = 2.61 at 35 cM, p = 0.0004), 3 (LOD = 1.82 at 84 cM, p = 0.0029), 8 (LOD = 1.92 at 135 cM, p = 0.0024) and 17 (LOD = 1.70 at 110 cM, p = 0.0044). A broad region on chromosome 4 supported evidence of linkage to variation in BMI, with the highest LOD = 2.66 at 168 cM (p = 0.0005). Two height loci and two BMI loci appear to confirm the existence of quantitative trait loci previously identified by other studies, providing important replicative data to allow further resolution of linkage regions suitable for positional cloning of these cardiovascular disease risk loci.

show abstract

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Loci Contributing to Adult Height and Body Mass Index in African American Families Ascertained for Type 2 Diabetes

Sale

Freedman²,

Hicks

et al. 2005

Annals of Human Genetics

View full text Add to dashboard Cite

show abstract

“…However, the list of genes and allelic variants involved in the determination of BS and BG variation is far from being complete. Several genome-wide scans have been conducted to identify susceptibility loci for bone size (e.g., Koller et al 2001;Deng et al 2003b) and adult height variation (e.g., Mukhopadhyay et al 2003;Willemsen et al 2004). With a few exceptions the results of the linkage analyses are so far largely inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Strong association between polymorphisms in ANKH locus and skeletal size traits

et al. 2006

View full text Add to dashboard Cite

Loss of bone strength is the main determinant of bone fragility. Bone strength is directly dependent on bone size (BS). A substantial portion of BS variation is attributable to genetic effects. However, the list of genes and allelic variants involved in the determination of BS variation is far from being complete. Polymorphisms in the ANKH gene have been shown to be associated with radiographic hand BS-related phenotypes. The present study examined the possible association of the ANKH gene with skeletal size and shape in order to test the universality of the ANKH effect on BS traits. Our sample consisted of a total of 212 ethnically homogeneous nuclear families (743 individuals) of European origin. Each individual was measured for body height, weight, and several other anthropometrical measurements, and genotyped for nine polymorphic markers (the average heterozygosity level was 0.4). We observed significant associations with practically all the anthropometrical phenotypes studied. More specifically, we found associations with body weight and height, limb length (P

show abstract

Assortative mating for human height: A meta‐analysis

Stulp

Simons

Grasman

et al. 2016

American J Hum Biol

View full text Add to dashboard Cite

ObjectivesThe study of assortative mating for height has a rich history in human biology. Although the positive correlation between the stature of spouses has often been noted in western populations, recent papers suggest that mating patterns for stature are not universal. The objective of this paper was to review the published evidence to examine the strength of and universality in assortative mating for height.MethodsWe conducted an extensive literature review and meta‐analysis. We started with published reviews but also searched through secondary databases. Our search led to 154 correlations of height between partners. We classified the populations as western and non‐western based on geography. These correlations were then analyzed via meta‐analytic techniques.Results148 of the correlations for partner heights were positive and the overall analysis indicates moderate positive assortative mating (r = .23). Although assortative mating was slightly stronger in countries that can be described as western compared to non‐western, this difference was not statistically significant. We found no evidence for a change in assortative mating for height over time. There was substantial residual heterogeneity in effect sizes and this heterogeneity was most pronounced in western countries.ConclusionsPositive assortative mating for height exists in human populations, but is modest in magnitude suggesting that height is not a major factor in mate choice. Future research is necessary to understand the underlying causes of the large amount of heterogeneity observed in the degree of assortative mating across human populations, which may stem from a combination of methodological and ecological differences.

show abstract

A Genome-Wide Scan for Loci Affecting Normal Adult Height in the Framingham Heart Study

Cited by 25 publications

References 35 publications

Loci Contributing to Adult Height and Body Mass Index in African American Families Ascertained for Type 2 Diabetes

Loci Contributing to Adult Height and Body Mass Index in African American Families Ascertained for Type 2 Diabetes

Strong association between polymorphisms in ANKH locus and skeletal size traits

Assortative mating for human height: A meta‐analysis

Contact Info

Product

Resources

About