A genome-wide overexpression screen revealsMycobacterium smegmatisgrowth inhibitors encoded by mycobacteriophage Hammy
Isabel Amaya,
Kaylia Edwards,
Bethany M. Wise
et al.
Abstract:During infection, bacteriophages produce diverse gene products to overcome bacterial anti-phage defenses, to outcompete other phages, and take over cellular processes. Even in the best-studied model phages, the roles of most phage-encoded gene products are unknown, and the phage population represents a largely untapped reservoir of novel gene functions. Considering the sheer size of this population, experimental screening methods are needed to sort through the enormous collection of available sequences and ide… Show more
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