A genome-wide association study of DSM-IV cannabis dependence

Abstract

Despite twin studies showing that 50–70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genomewide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis dependent cases with 2,346 cannabis exposed nondependent controls was conducted using logistic regression in PLINK. None of the 948,142 SNPs met genomewide significance (p < E−8). The lowest p-values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, p-values at E−7) in the ANKFN1 gene. While replication is required, this study represents an important first step towards clarifying the biological underpinnings of cannabis dependence.

Recovery from cannabis use disorders: Abstinence versus moderation and treatment-assisted recovery versus natural recovery.

“…Another longitudinal study of children and adolescents demonstrated support for a particular developmental pathway to adolescent cannabis use disorders; whereby severity of early childhood maltreatment potentiated less adaptive childhood personality functioning, followed by externalizing problems in preadolescence, and ultimately, adolescent cannabis abuse and dependence symptoms (Oshri, Rogosch, Burnette, & Cicchetti, 2011). Interestingly, a developmental pathway from child maltreatment to adolescent cannabis use disorder symptoms via personality and preadolescent internalizing problems was not supported (Oshri et al, 2011 (Agrawal et al, 2011;Verweij et al, 2012). It is clear that in order to further our understanding of the etiology of cannabis use disorders, continued development and validation of etiological models of cannabis use disorders will be required, which will necessarily involve the continued use of longitudinal studies and the integration of biopsychosocial areas of research.…”

“…The fact that treatment-assisted participants more readily identified genetics/predisposition as an etiological category also might suggest that they were taught this treatment, but it is also possible that their cannabis use disorders were relatively and genuinely more influenced by genetics factors in light of their more frequent reports of family addiction problems. There is indeed solid evidence that cannabis use and cannabis use disorders have heritable components (Agrawal et al, 2011;Verweij et al, 2012).…”

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample

“…Recently, several GWASs have been published for alcohol dependence (Gelernter et al, 2014a;Kapoor et al, 2014;Treutlein et al, 2009;Wetherill et al, 2015), nicotine dependence (Gelernter et al, 2015;Loukola et al, 2014), cannabis dependence (Agrawal et al, 2011), and opioid dependence (Nielsen et al, 2010). However, the GWAS sometimes did not provide conclusive evidence for genetic factors previously reported as associated with dependence in single-candidate gene studies.…”

Les addictions sous l’angle de la génétique

“…La première étude pangénomique de la dépendance au cannabis comparait 708 patients dépendants et 2 346 sujets exposés au cannabis, mais non dépen-dants ; elle n'avait pas permis d'identifier de variant dont l'association à la dépendance au cannabis était statistiquement validée après correction pour les tests multiples [25]. Des variants du gène ANKFN1 (ankyrin repeat and fibronectin type-III domain-containing protein 1), codant pour une protéine de fonction peu connue, avaient été impliqués dans des associations nominales avec la dépendance au cannabis.…”