A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries)

Ren, Xue; Yang, Guangli; Peng, Weifeng; Zhang, Yongxin; Zhang, Min; Chen, Zehui; Wu, Fu‐An; Kantanen, Juha; Shen, Min; Li, Menghua

doi:10.1038/srep21111

Cited by 28 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, metaxin 2 (MTX2) and Homeobox (HOXD) cluster (HOXD9 & HOXD3) genes were identified affecting the polyceraty phenotype in Jacob, Navajo-Churro, Damara and Sishui Fur sheep breeds using GWAS. Both genes are responsible for horn existence and determining horn number in sheep [87][88][89][90]. Genes for wool, coat color and horn traits, and their respective location on the sheep genome are presented in the table below ( Table 5)…”

Section: Genes Affecting Wool Coat Color and Horn Phenotypic Traitsmentioning

confidence: 99%

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Gebreselassie

Berihulay

Jiang

et al. 2019

Animals

View full text Add to dashboard Cite

Simple Summary: Sheep is one of the most economically important animals used as a source of meat, milk, wool, and fur for human society. These commodities are essential for human being. Body growth, body weight, carcass quality, fat percent, fertility, milk yield, wool, horn type and coat color are essential and useful sheep traits. Understanding the genetic background of these traits is paramount to increase the production and productivity of domestic animals. The availability of genomic data, development of molecular breeding techniques, and genome technologies have come to play a vital role in understanding the genetic background of different animal traits. This is directly or indirectly helpful for the practice of genetic improvement of economically important traits in sheep. The identification of genomic regions, genes associated with phenotypic traits, and description of gene function are some of the applied research activities to understand the genetics of livestock species. The aim of this review is to discuss and summarize different reported research findings on identified genomic regions and candidate genes related with economically important traits as well as gene annotation in sheep.Abstract: Sheep (Ovis aries) is one of the most economically, culturally, and socially important domestic animals. They are reared primarily for meat, milk, wool, and fur production. Sheep were reared using natural selection for a long period of time to offer these traits. In fact, this production system has been slowing the productivity and production potential of the sheep. To improve production efficiency and productivity of this animal through genetic improvement technologies, understanding the genetic background of traits such as body growth, weight, carcass quality, fat percent, fertility, milk yield, wool quality, horn type, and coat color is essential. With the development and utilization of animal genotyping technologies and gene identification methods, many functional genes and genetic variants associated with economically important phenotypic traits have been identified and annotated. This is useful and presented an opportunity to increase the pace of animal genetic gain. Quantitative trait loci and genome wide association study have been playing an important role in identifying candidate genes and animal characterization. This review provides comprehensive information on the identified genomic regions and candidate genes associated with production and reproduction traits, and gene function in sheep.

show abstract

Section: Genes Affecting Wool Coat Color and Horn Phenotypic Traitsmentioning

confidence: 99%

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Gebreselassie

Berihulay

Jiang

et al. 2019

Animals

View full text Add to dashboard Cite

show abstract

“…From 2011 to 2015, several genes (e.g., RXFP2, MTX2 and HOX gene clusters) and QTLs affecting horn development on chromosome 10 were identified in multiple sheep breeds [11,27,[32][33][34][59][60][61][62][63][64][65] . On chromosome 2, a genomic region of 132.0-133.1 Mb that contains the HOXD gene cluster and EVX2 and KIAA1715 genes was identified using GWAS [66] . These genes are related to the formation of limbs and genital buds [66] .…”

Section: Horn Traitsmentioning

confidence: 99%

“…On chromosome 2, a genomic region of 132.0-133.1 Mb that contains the HOXD gene cluster and EVX2 and KIAA1715 genes was identified using GWAS [66] . These genes are related to the formation of limbs and genital buds [66] . A similar genomic region (131.9-132.6 Mb) on chromosome 2 is associated with the four-horn phenotype, and MTX2 and HOXD cluster within this region were revealed to be involved in horn ontogenesis [67] .…”

Section: Horn Traitsmentioning

confidence: 99%

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Xu¹,

Li²

2017

Front. Agr. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Sheep are one of the most economically important domesticated animals for human society. However, genetic improvements for the key traits associated with meat, growth, milk, wool, reproduction, horns and tails progress slowly using conventional crossbreeding methods. With the development and utilization of highthroughput screening technologies over the last decade, a list of functional genes and genetic variants associated with these traits has been identified. This review covers recent genome-wide studies on sheep productive traits using high-throughput screening technologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genome level (e.g., genome-wide association studies), transcriptome and DNA methylation sequences. Additionally, comprehensive information on functional genes and genetic variants associated with economically important traits in sheep is provided.

show abstract

“…) and Sishui Fur sheep (Ren et al . ). However, the four‐horned locus is still unknown in other Chinese breeds.…”

Section: Horn Classifications and Their Frequencies In The Three Sheementioning

confidence: 97%

“…; Ren et al . ). The four‐horned locus that we identified was downstream of the metaxin 2 ( MTX2 ) gene and the HOXD gene cluster.…”

Section: Horn Classifications and Their Frequencies In The Three Sheementioning

confidence: 97%

Mapping the four‐horned locus and testing the polled locus in three Chinese sheep breeds

Zhou

Yun

et al. 2016

Animal Genetics

View full text Add to dashboard Cite

Four-horned sheep are an ideal animal model for illuminating the genetic basis of horn development. The objective of this study was to locate the genetic region responsible for the four-horned phenotype and to verify a previously reported polled locus in three Chinese breeds. A genome-wide association study (GWAS) was performed using 34 two-horned and 32 four-horned sheep from three Chinese indigenous breeds: Altay, Mongolian and Sishui Fur sheep. The top two significant single nucleotide polymorphisms (SNPs) associated with the four-horned phenotype were both located in a region spanning positions 132.6 to 132.7 Mb on sheep chromosome 2. Similar locations for the four-horned trait were previously identified in Jacob, Navajo-Churro, Damara and Sishui Fur sheep, suggesting a common genetic component underlying the four-horned phenotype. The two identified SNPs were both downstream of the metaxin 2 (MTX2) gene and the HOXD gene cluster. For the top SNP-OAR2:g.132619300G>A-the strong associations of the AA and AG genotypes with the four-horned phenotype and the GG genotype with the two-horned phenotype indicated the dominant inheritance of the four-horned trait. No significant SNPs for the polled phenotype were identified in the GWAS analysis, and a PCR analysis for the detection of the 1.8-kb insertion associated with polled sheep in other breeds failed to verify the association with polledness in the three Chinese breeds. This study supports the hypothesis that two different loci are responsible for horn existence and number. This study contributes to the understanding of the molecular regulation of horn development and enriches the knowledge of qualitative traits in domestic animals.

show abstract

A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries)

Cited by 28 publications

References 39 publications

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries)

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Mapping the four‐horned locus and testing the polled locus in three Chinese sheep breeds

Contact Info

Product

Resources

About