A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder

Xie, Zengyan; Yang, Xianyan; Deng, Xiaoya; Ma, Ming-Yue; Shu, Kunxian

doi:10.3390/ijms18122763

Cited by 11 publications

(4 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As for bipolar disorder, serum levels of FGF2 are higher in patients with manic episode than those in healthy controls (Liu et al, 2014). FGF2 is related to bipolar disorder at the genetic level of humans (Xie et al, 2017). Similarly, FGFR2 is found to be associated with bipolar disorder through SNPs genotyping in humans (Wang et al, 2012).…”

Section: Fgfs and Depressionmentioning

confidence: 99%

Fibroblast Growth Factors in Depression

Deng

Zhang

et al. 2019

Front. Pharmacol.

View full text Add to dashboard Cite

Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. In recent years, studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Here, we reviewed the correlation between some members of the FGF system and depression.

show abstract

Section: Fgfs and Depressionmentioning

confidence: 99%

Fibroblast Growth Factors in Depression

Deng

Zhang

et al. 2019

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…It was noteworthy that a SNP in CUL4A was found to be associated with bipolar disorder in a genome-wide association study (GWAS) ( Stahl et al, 2019 ). Moreover, a recent analysis revealed CUL4A as one of the 112 hub genes in the complex network of GWAS-identified genes in bipolar disorder ( Xie et al, 2017 ). Therefore, the differential G-to-A RNA editing in Cul4a were probably in line with a potential role of the gene in emotional stress and mood disorders.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome-Wide Identification of G-to-A RNA Editing in Chronic Social Defeat Stress Mouse Models

Ren

Wei

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Emerging evidence suggests that RNA editing is associated with stress, neurological diseases, and psychiatric disorders. However, the role of G-to-A RNA editing in chronic social defeat stress (CSDS) remains unclear. We herein identified G-to-A RNA editing and its changes in the ventral tegmental area (VTA), a key region of the brain reward system, in CSDS mouse models under emotional stress (ES) and physiological stress (PS) conditions. Our results revealed 3812 high-confidence G-to-A editing events. Among them, 56 events were significantly downregulated while 23 significantly upregulated in CSDS compared to controls. Moreover, divergent editing patterns were observed between CSDS mice under ES and PS conditions, with 42 and 21 events significantly upregulated in PS and ES, respectively. Interestingly, differential RNA editing was enriched in genes with multiple editing events. Genes differentially edited in CSDS included those genetically associated with mental or neurodevelopmental disorders, especially mood disorders, such as FAT atypical cadherin 1 and solute carrier family 6 member 1. Notably, changes of G-to-A RNA editing were also implicated in ionotropic glutamate receptors, a group of well-known targets of adenosine-to-inosine RNA editing. Such results demonstrate dynamic G-to-A RNA editing changes in the brain of CSDS mouse models, underlining its role as a potential molecular mechanism of CSDS and stress-related diseases.

show abstract

“…EphB1 knocked-out mice exhibit aberrant thalamic-cortical axon guidance (Robichaux et al, 2014), which, as discussed in the previous section, is a usual finding in both ASD and WS. FBXL13 encodes a protein ubiquitin ligase associated with the Class 1 MHC mediated antigen processing and presentation and has been highlighted as one core gene involved in bipolar disorder (Xie et al, 2017). FOXO4 encodes a fork-head transcription factor targeted by USP7, a candidate for ASD and for neurodevelopmental disorders involving speech delay and altered behavior (Fountain et al, 2019).…”

Section: Functional Characterization Of Genes Of Interestmentioning

confidence: 99%

Autism and Williams syndrome: dissimilar socio-cognitive profiles with similar patterns of abnormal gene expression in the blood

Niego

Benítez‐Burraco

2020

Preprint

View full text Add to dashboard Cite

Autism Spectrum Disorders (ASD) and Williams Syndrome (WS) are complex cognitive conditions exhibiting quite opposite features in the social domain: whereas people with ASD are mostly hyposocial, subjects with WS are usually reported as hypersocial. At the same time, ASD and WS share some common underlying behavioral and cognitive deficits. It is not clear, however, which genes account for the attested differences (and similarities) in the socio-cognitive domain. In this paper we adopted a comparative-molecular approach and looked for genes that might be differentially (or similarly) regulated in the blood of people with these conditions. We found a significant overlap between genes dysregulated in the blood of patients compared to neurotypical controls, with most of them being upregulated or, in some cases, downregulated. Still, genes with similar expression trends can exhibit quantitative differences between conditions, with most of them being more dysregulated in WS than in ASD. Differentially-expressed genes are involved in aspects of brain development and function (particularly, dendritogenesis) and are expressed in brain areas (particularly, the cerebellum, the thalamus and the striatum) of relevance for the ASD and the WS etiopathogenesis. Overall, these genes emerge as promising candidates for the similarities and differences between the ASD and the WS socio-cognitive profiles.

show abstract

A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder

Cited by 11 publications

References 119 publications

Fibroblast Growth Factors in Depression

Fibroblast Growth Factors in Depression

Transcriptome-Wide Identification of G-to-A RNA Editing in Chronic Social Defeat Stress Mouse Models

Autism and Williams syndrome: dissimilar socio-cognitive profiles with similar patterns of abnormal gene expression in the blood

Contact Info

Product

Resources

About