A genome-wide assessment of adrenocorticotropin action in the Y1 mouse adrenal tumor cell line

Schimmer, Bernard P.; Cordova, Martha; Cheng, Henry S.; Tsao, Andrew; Morris, Quaid

doi:10.1016/j.mce.2006.12.024

Cited by 14 publications

(9 citation statements)

References 31 publications

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“…One hundred and twenty nine transcripts were up-regulated and 127 were down-regulated by this treatment, and 45 of these matched transcripts were regulated by ACTH. Interestingly, most of the ACTH-regulated transcripts assigned to the Ca 2+ signaling pathway by these criteria also fulfilled criteria for activation via the cAMP pathway (Schimmer et al 2007), further indicating that Ca 2+ and cAMP are not independent, but closely interconnected.…”

Section: Effects Of Acth On Electrical Properties Of Adrenocortical Cmentioning

confidence: 97%

“…To prevent cell toxicity, these reactive oxygen species (ROS) are metabolized to isocaproic acid by a family of aldo-keto reductases (AKR), including Akr1b8 and Akr1b7 in mice and AKR1B10 in humans (Lefrançois- Martinez et al 1999, Pastel et al 2012. These enzymes are highly expressed in the adrenal glands, and their levels of expression are correlated with the level of ACTH (Schimmer et al 2007).…”

Section: Effects Of Acth On Protection Against Reactive Oxygen Speciementioning

confidence: 99%

“…Epacs also enhance the expression of both Cav3.2 and functional Ca 2+ channels . The contribution of Ca 2+ to genome-wide actions of ACTH has been explored in Y1 cells (Schimmer et al 2007). Cells were treated with the Ca 2+ ionophore A23187 (10 μM) for 24 h to promote Ca 2+ influx and changes in transcript accumulation were profiled using the 1.7 K human cDNA array.…”

Section: Effects Of Acth On Electrical Properties Of Adrenocortical Cmentioning

confidence: 99%

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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo‐Payet

2016

Journal of Molecular Endocrinology

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The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on ACTH receptor properties, the first part of the review covers the role of ACTH in steroidogenesis and steroid secretion. We highlight the mechanisms explaining the differential acute vs chronic effects of ACTH on aldosterone and glucocorticoid secretion. The second part summarizes the effects of ACTH on adrenal growth, addressing its role as either a mitogenic or a differentiating factor. We then review the mechanisms involved in steroid secretion, from the classical Cyclic adenosine monophosphate second messenger system to various signaling cascades. We also consider how the interaction between the extracellular matrix and the cytoskeleton may trigger activation of signaling platforms potentially stimulating or repressing the steroidogenic potency of ACTH. Finally, we consider the extra-adrenal actions of ACTH, in particular its role in differentiation in a variety of cell types, in addition to its known lipolytic effects on adipocytes. In each section, we endeavor to correlate basic mechanisms of ACTH function with the pathological consequences of ACTH signaling deficiency and of overproduction of ACTH.

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Section: Effects Of Acth On Electrical Properties Of Adrenocortical Cmentioning

confidence: 97%

Section: Effects Of Acth On Protection Against Reactive Oxygen Speciementioning

confidence: 99%

Section: Effects Of Acth On Electrical Properties Of Adrenocortical Cmentioning

confidence: 99%

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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo‐Payet

2016

Journal of Molecular Endocrinology

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“…In past reports on global profiles of gene expression induced by ACTH in the Y1 mouse adrenal cells, 1,386 of 5,655 transcripts were affected by corticotrophin, and~45% of them were up-regulated (40,41). The up-regulated transcripts are involved mainly in steroid biosynthesis and metabolism while the down-regulated transcripts are connected with cell proliferation, nuclear transport and RNA processing.…”

Section: Discussionmentioning

confidence: 99%

Cerebellin and des-cerebellin exert ACTH-like effects on corticosterone secretion and the intracellular signaling pathway gene expression in cultured rat adrenocortical cells - DNA microarray and QPCR studies

Ruciński

Ziółkowska²,

Szyszka³

et al. 2009

Int J Mol Med

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Abstract. Precerebellins (Cbln) belong to the C1q/TNF superfamily of secreted proteins which have diverse functions. They are abundantly expressed in the cerebellum, however, three of them are also expressed in the rat adrenal gland. All members of the Cbln family form homomeric and heteromeric complexes with each other in vitro and it was suggested that such complexes play a crucial role in normal development of the cerebellum. The aim of our study was to investigate whether Cbln1-derived peptides, cerebellin (CER) and des-Ser 1 -cerebellin (desCER) are involved in regulating biological functions of rat adrenocortical cells. In the primary culture of rat adrenocortical cells, 24 h exposure to CER or desCER notably stimulated corticosterone output and inhibited proliferative activity and similar effects were evoked by ACTH. To study gene transcript regulation by CER, desCER and ACTH, we applied Oligo GEArray ® DNA Microarray: Rat Signal Transduction Pathway Finder™. In relation to the control culture, 13 of the 113 transcripts present on the array were differentially expressed. These transcripts were either up-or down-regulated by ACTH and/or CER or desCER treatment. Validation of DNA Microarray data by QPCR revealed that only 5 of 13 genes studied were differentially expressed. Of those genes, Fos and Icam1 were up-regulated and Egr1 was down-regulated by ACTH, CER and desCER. The remaining two genes, Fasn (insulin signaling pathway) and Hspb1 (HSP27) (stress signaling pathway), were regulated only by CER and desCER, but not by ACTH. Thus, both CER and desCER have effects similar to and different from corticotrophin on the intracellular signaling pathway gene expression in cultured rat adrenocortical cells.

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“…Tyr pelas JNKK1 e JNKK2, conhecidas como MAPK quinase 4 e 7 (MKK4/7 (Fassnacht et al, 2003;Schimmer et al, 2007;Costa et al, 2008;Parmar et …”

Section: ____________________________________________________________unclassified

Vias de sinalização e efeito biológico da corticotropina (ACTH), do peptídeo NH2-terminal da pró-opiomelanocortina (N-POMC) e do fator de crescimento de fibroblastos (FGF2) em culturas primárias de células da suprarrenal de rato.

Mattos¹

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A genome-wide assessment of adrenocorticotropin action in the Y1 mouse adrenal tumor cell line

Cited by 14 publications

References 31 publications

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Cerebellin and des-cerebellin exert ACTH-like effects on corticosterone secretion and the intracellular signaling pathway gene expression in cultured rat adrenocortical cells - DNA microarray and QPCR studies

Vias de sinalização e efeito biológico da corticotropina (ACTH), do peptídeo NH2-terminal da pró-opiomelanocortina (N-POMC) e do fator de crescimento de fibroblastos (FGF2) em culturas primárias de células da suprarrenal de rato.

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