A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms

Segalés, Joaquím; Urniza, Alicia; Alegre, A.; Bru, T.; Crisci, Elisa; Nofrarías, Miquel; López-Soria, Sergio; Balasch, M.; Sibila, Marina; Xu, Zhouyi; Chu, Hsien-Jue; Fraile, Lorenzo; Plana-Durán, J.

doi:10.1016/j.vaccine.2009.09.084

Cited by 70 publications

(39 citation statements)

References 33 publications

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“…Batches which performed commercial circovirus vaccine in their pigs presented (p < 0.01) lower values for TFI, TDURFAT, FCR and MORT compared to those that did not. This reduction in mortality and the improvement in feed efficiency in vaccinated pigs also were observed by Segales et al (2009) andJacela et al (2011). Batches that received two antibiotics treatments or less during the GF period tended (p = 0.07) to have a lower MORT than batches that were treated three or more times.…”

Section: P S Agostini Et Al / Span J Agric Ressupporting

confidence: 78%

Descriptive study of production factors affecting performance traits in growing-finishing pigs in Spain

Agostini

Gasa

Manzanilla

et al. 2013

Span. j. agric. res.

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The objective of this study was to build up a data set including productive performance and production factors data of growing-finishing (GF) pigs in Spain in order to perform a representative and reliable description of the traits of Spanish growing-finishing pig industry. Data from 764 batches from 452 farms belonging to nine companies (1,157,212 pigs) were collected between 2008 and 2010 through a survey including five parts: general, facilities, feeding, health status and performance. Most studied farms had only GF pigs on their facilities (94.7%), produced ‘industrial’ pigs (86.7%), had entire male and female (59.5%) and Pietrain-sired pigs (70.0%), housed between 13-20 pigs per pen (87.2%), had  50% of slatted floor (70%), single-space dry feeder (54.0%), nipple drinker (88.7%) and automatic ventilation systems (71.2%). A 75.0% of the farms used three feeding phases using mainly pelleted diets (91.0%), 61.3% performed three or more antibiotic treatments and 36.5% obtained water from the public supply. Continuous variables studied had the following average values: number of pigs placed per batch, 1,515 pigs; initial and final body weight, 19.0 and 108 kg; length of GF period, 136 days; culling rate, 1.4%; barn occupation, 99.7%; feed intake per pig and fattening cycle, 244 kg; daily gain, 0.657 kg; feed conversion ratio, 2.77 kg kg-1 and mortality rate, 4.3%. Data reflecting the practical situation of the Spanish growing and finishing pig production and it may contribute to develop new strategies in order to improve the productive and economic efficiency of GF pig units.

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Section: P S Agostini Et Al / Span J Agric Ressupporting

confidence: 78%

Descriptive study of production factors affecting performance traits in growing-finishing pigs in Spain

Agostini

Gasa

Manzanilla

et al. 2013

Span. j. agric. res.

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“…Interference with vaccination against swine influenza virus associated with the presence of passively acquired antibodies has been documented (3,23,27,38); however, evidence of passive antibody interference with PCV2 vaccination has not been confirmed under experimental conditions (30). Furthermore, PCV2 vaccines have been highly effective in the field, and almost all pigs are seropositive to PCV2 at the time of PCV2 vaccination (9,19,21,41). In experimental PCV2 challenge models, outcomes are often similar between vaccine treatment groups (11,24), and conclusions often lack power.…”

Section: Discussionmentioning

confidence: 99%

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

O'Neill

Shen

Lin

et al. 2011

Clin Vaccine Immunol

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Porcine circovirus type 2 (PCV2) vaccines have become widely used since they became available in 2006. It is not uncommon for producers to use PCV2 vaccines in pigs younger than what is approved by manufacturers. The objective of this study was to determine the efficacy of a chimeric and a subunit PCV2 vaccine administered at 5 or 21 days of age. Forty-eight PCV2-naïve piglets were randomly divided into six groups of eight pigs each. Vaccination was done at day 5 or day 21, followed by triple challenge with PCV2, porcine parvovirus (PPV), and porcine reproductive and respiratory syndrome virus (PRRSV) at day 49. Vaccinated pigs seroconverted to PCV2 approximately 14 days postvaccination and had a detectable neutralizing antibody response by 21 days postvaccination regardless of age at vaccination. At day 49, the pigs vaccinated with the chimeric vaccine had significantly higher levels of neutralizing antibodies than the pigs vaccinated with the subunit vaccine. After challenge, vaccinated pigs had significantly decreased levels of PCV2 viremia and a decreased prevalence and severity of microscopic lesions compared to the positive-control group, which had severe lymphoid lesions associated with abundant PCV2 antigen, compatible with PCV-associated disease. The results of this study indicate that, under the conditions of this study, vaccination of PCV2-naïve pigs at day 5 or day 21 resulted in development of a detectable humoral immune response and provided reduction or complete protection against PCV2 viremia and PCV2-associated lesions after triple challenge with PCV2, PPV, and PRRSV.

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“…Various commercially available killed PCV2 vaccines are being used worldwide, and their efficacies have been demonstrated under both experimental conditions (13,25,29,30,40) and field conditions (5,12,17,19,39). PCV2 vaccination is recommended for usage in weaned pigs at about 3 weeks of age or older.…”

Section: Discussionmentioning

confidence: 99%

Porcine Reproductive and Respiratory Syndrome Virus Infection at the Time of Porcine Circovirus Type 2 Vaccination Has No Impact on Vaccine Efficacy

Sinha

Shen

Schalk

et al. 2010

Clin Vaccine Immunol

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Several porcine circovirus type 2 (PCV2) vaccines are now commercially available and have been shown to be effective at decreasing the occurrence of porcine circovirus-associated disease (PCVAD). Many herds are coinfected with PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV). Some producers and veterinarians are concerned that if pigs are vaccinated for PCV2 at or near the time that they are typically infected with PRRSV, the efficacy of the PCV2 vaccine will be compromised. The impact of PRRSV on PCV2 vaccination is unclear and has not been investigated under controlled conditions. The objective of the present study was to determine whether the presence of PRRSV viremia has an effect on the efficacy of commercial PCV2 vaccinations. Three-week-old PCV2-negative conventional pigs with passively derived anti-PCV2 antibodies were either vaccinated with one of three commercial PCV2 vaccines or left nonvaccinated. A portion of the pigs were infected with PRRSV 1 week prior to PCV2 vaccination. To determine vaccine efficacy, a PCV2 challenge was conducted at 8 weeks of age. PCV2 vaccination, regardless of PRRSV infection status at the time of vaccination, was similarly effective in inducing an anti-PCV2 IgG response in the presence of maternally derived immunity and in protecting the pigs from PCV2 challenge, as determined by a reduction in the level of PCV2 viremia and a reduction in the prevalence and amount of PCV2 antigen in lymphoid tissues in vaccinated pigs compared to nonvaccinated pigs. The results indicate that acute PRRSV infection at the time of PCV2 vaccination has no adverse effect on PCV2 vaccine efficacy.

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A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms

Cited by 70 publications

References 33 publications

Descriptive study of production factors affecting performance traits in growing-finishing pigs in Spain

Descriptive study of production factors affecting performance traits in growing-finishing pigs in Spain

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

Porcine Reproductive and Respiratory Syndrome Virus Infection at the Time of Porcine Circovirus Type 2 Vaccination Has No Impact on Vaccine Efficacy

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