A genetic variant of
CXCR4
predicts pegylated interferon-alpha treatment response in HBeAg-positive chronic hepatitis B patients
Mengqi Luo,
Chao Dong,
Xinghe Liang
et al.
Abstract:Chemokine receptor 4 (CXCR4) plays a vital role in immunoregulation during hepatitis B virus (HBV) infection. This study aimed to screen single-nucleotide polymorphisms (SNPs) of
CXCR4
for predicting pegylated interferon-alpha (PegIFNα) therapy response in chronic hepatitis B (CHB) patients. This retrospective cohort study enrolled a total of 945 CHB patients in two cohorts (Cohort 1,
n
= 238; Cohort 2,
n
= 707), and all the patients were … Show more
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