A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis

Association Analysis of Single Nucleotide Polymorphisms in miR-146a and miR-196a2 on the Prevalence of Cancer in Elderly Japanese: A Case-Control Study

“…This G to C genetic modification reduces the secondary structure stability, since C has lower free energy (ΔG=-40 kcal/ mol) than G allele (ΔG=-42 kcal/mol) showed reduced mature miR-146a adversely influencing the inhibition of the target tumor suppressor genes such as IL-1 receptorassociated kinase 1 (IRAK1), TNF receptor-associated factor 6 (TRAF6), and papillary thyroid carcinoma 1 (PTC1), G allele down regulates the mature miR-146a and increased cell proliferation homozygous GG carriers had higher matured miR-146a expression level leading to higher cancer susceptibility (Xu et al, 2008) Furthermore, rs2910164 CC genotype was associated with breast cancer by increasing the binding affinity to BRCA1 and/or BRCA2 oncogenes and alternatively may disturb the wellknown NF-kB apoptotic pathway (Taganov et al, 2006). On the contrary, our results indicated that rs2910164 has no statistical significance with over all cancer which is consistent with previous studies indicating that either rs2910164 (G/C) polymorphism has no significant association or decreasing/protective effect to cancer development (Xu et al, 2013;Xu et al, 2011) even more specifically with liver cancer (Zhou et al, 2011;, colorectal cancer (Hezova et al, 2012, Du et al, 2014, digestive system including gastric cancer (Kupcinskas et al, 2013;Li et al, 2014). The rs11614913 is located the passenger strand of the 3' end of pre-miR-196a2 sequence, which negatively effects the miR-196a2 maturation and its interaction(s) with other miRs or gene(s) and also mature miR-196a2 level was reduced in CC homozygous variant than TT homozygous genotype was found in previous studies (Duan et al, 2008).…”

Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis

“…However, the number of included studies was somewhat limited. Some meta-analyses of miR-146a only included 3 or 4 case-control studies (Qiu et al, 2011;Wu et al, 2013;Li et al, 2014), and meta-analyses of miR-196a-2 contained only one or two studies (Guo et al, 2012;Zhang et al, 2012;Wang et al, 2013). Considering the controversial conclusions extant in the published studies and the limitations of previous meta-analyses, it is necessary that an updated meta-analysis be conducted that includes a larger sample size to measure the correlations of miR-146a and miR196a-2 with the risk of gastric cancer.…”

A comprehensive review of microRNA-related polymorphisms in gastric cancer

“…Regarding the first report of the polymorphism in gastric cancer, Zeng et al (2010) found that subjects with pre-miR-146a rs2910164 GC/GG genotypes had a 1.58-fold elevated risk of gastric cancer compared to carriers of the CC genotype [95% confidence interval (CI) = 1.11-2.20; P = 0.009]. For SNPs in pri-miRNA, Xu et al (2014b) reported an rs629367 polymorphism located in pri-let-7a-2 and the CC genotype was associated with an increased risk (Xu et al, 2014a,c) let-7a-2 rs629367, rs1143770 (Xu et al, 2014a) let-7f-2 rs17276588 miR-124 rs531564 (Zhou et al, 2012b;Xu et al, 2015) miR-26a-1 rs7372209 (Zhou et al, 2012b;Stenholm et al, 2013;Xu et al, 2015) miR-938 rs2505901 (Arisawa et al, 2012) pre-miRNA miR-146a rs2910164 (Okubo et al, 2010;Zeng et al, 2010;Hishida et al, 2011;Wang et al, 2012;Zhou et al, 2012a,b;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wu et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Li et al, 2014b;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2014dXu et al, , 2015 rs11614913 (Okubo et al, 2010;Peng et al, 2010;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wang et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2015) miR-149 rs2292832 …”

“…Over the past several years, the association of the pre-miR-146a rs2910164 polymorphism with risk of gastric cancer has been extensively investigated (Okubo et al, 2010;Zeng et al, 2010;Hishida et al, 2011;Wang et al, 2012;Zhou et al, 2012a,b;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wu et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Li et al, 2014b;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2014dXu et al, , 2015. In total, 18 studies were involved, including 10 case-control studies, 6 meta-analyses, and 2 case-only studies.…”