A genetic variant in miR‐100 is a protective factor of childhood acute lymphoblastic leukemia

Abstract

Background In the past decade, miR‐100, miR‐146a, and miR‐210 were reported to be dysregulated in childhood acute lymphoblastic leukemia (ALL). However, effects of genetic variants in these three microRNAs have not been investigated in Chinese population. Methods In this study, we conducted a case‐control study to evaluate the relationship between genetic variants in miR‐100, miR‐146a, and miR‐210 and the risk of childhood ALL in Chinese population. Subsequently, plasma expression level of miR‐100 was also detected. Result We found that subjects carrying mutant homozygous TT genotype of miR‐100 rs543412 had a statistically significantly decreased risk of childhood ALL (adjusted odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.55‐0.97, P = 0.029). This protective effect was also observed among subjects whose parents were ever drinkers (adjusted OR = 0.53, 95% CI = 0.29‐0.94), or whose living house were ever painted (adjusted OR = 0.57, 95% CI = 0.34‐0.94). Besides, rs543412 variant homozygous TT had a significantly protective role in patients with childhood B‐ALL. Finally, we found that expression level of miR‐100 in plasma of childhood ALL cases was significantly higher than that of noncancer controls. Conclusion Our study suggested that there was significant association between the polymorphisms in miR‐100 (rs543412) and decreased susceptibility to childhood ALL.

Diagnostic, prognostic and predictive values of miR-100 and miR-210 in pediatric acute lymphoblastic Leukemia

“…On the other hand, no significant association was detected with age, sex, BM cellularity, karyotyping, organomegaly, lymphadenopathy, risk stratification, TLC, platelet count, peripheral blood blast %, or BM blast%. These data are concordant to that observed by Xue et al [23], who found a significant association between miR-100 expression and B-ALL phenotype. Similarly, Li et al [11] reported that lower expression of miR-100 was found in patients with high-risk prognostic factors, T-ALL patients and in patients carrying the MLL-rearrangement and BCR-ABL fusion genes, suggesting that miR-100 expression is cell-type specific.…”

“…These data are in agreement with many studies in literature reported down-regulation of miR-100 in ALL patients compared to control group [11,[20][21][22]. Xue et al demonstrated also that miR-100 is a good prognostic factor for ALL, and the genetic variant of miR-100 (rs543412) was remarkably associated with decreased childhood ALL risk [23], though, he found a significant increase in the plasma level of miR-100 in ALL patients compared to control group. This discrepancy in results may be due to the different biological characteristic between plasma samples and BM samples.…”

LncRNA‐MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR‐205‐PTK7 pathway

“…MiRNAs also participate in the complicated pathogenesis of ALL. 32,33 miR-205 has been recognized to function as a tumor suppressor gene in multiple tumors. 34,35 In this study, we demonstrated that miR-205 was downregulated in ALL patient samples.…”

“…MiRNAs also participate in the complicated pathogenesis of ALL 32,33 . miR‐205 has been recognized to function as a tumor suppressor gene in multiple tumors 34,35 .…”

Association Between the miR-146a Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population

“…This result was successfully replicated in two Chinese case-control studies (Liu et al, 2018 ; Pei et al, 2020 ). In contrast, three studies from Thailand, India and China failed to replicate the results (Chansing et al, 2016 ; Devanandan et al, 2019 ; Xue et al, 2019 ). Considering the conflicting results, whether miR-146a rs2910164 is associated with childhood ALL in Asian populations remains to be elucidated.…”