A genetic overview of 23Y-STR markers in UAE population

Nazir, Muhammad Shahid; Alhaddad, Hasan; Alenizi, Mohammad; Alenizi, Homod; Taqi, Zainab J.; Sanqoor, Sheikha; Alrazouqi, Amna; Hassan, A.M. El; Alfalasi, Roudha; Gaur, Suruchika; Jaber, Jaber Al; Ziab, Jassem; Al-Harbi, Enas; Budowle, Bruce

doi:10.1016/j.fsigen.2016.04.009

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…Comparison with other datasets required reduction of the number of STRs to a shared set of seventeen (Yfiler loci). Comparison is shown of the four governorate samples from the current study (stars) with an independent dataset of 156 Y-STR haplotypes from the same country (‘Bahrain’ (YHRD data)), and other datasets from the region: Saudi Arabia ( n = 597 (Khubrani et al 2018 )), Iraq ( n = 1354 (Purps et al 2014 )), Iran ( n = 2333 (Nasidze et al 2003 ; Alshamali et al 2009 ; Roewer et al 2009 )); Kuwait ( n = 534 (Triki-Fendri et al 2010 ; Taqi et al 2015 )), UAE ( n = 809 (Nazir et al 2016 )), Yemen (n = 149 (YHRD data)) and Lebanon ( n = 555 (YHRD data)) …”

Section: Resultsmentioning

confidence: 99%

Geographical structuring and low diversity of paternal lineages in Bahrain shown by analysis of 27 Y-STRs

et al. 2020

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We have determined the distribution of Y-chromosomal haplotypes and predicted haplogroups in the ethnically diverse Kingdom of Bahrain, a small archipelago in the Arabian Gulf. Paternal population structure within Bahrain was investigated using the 27 Y-STRs (short tandem repeats) in the Yfiler Plus kit to generate haplotypes from 562 unrelated Bahraini males, sub-divided into four geographical regions—Northern, Capital, Southern and Muharraq. Yfiler Plus provided a significant improvement over the 17-locus Yfiler kit in discrimination capacity (from 77% to 87.5% overall), but discrimination capacity differed widely between regions from 98.4% in Muharraq to 75.2% in the Northern region, an unusually low value possibly resulting from recent rapid population expansion. Clusters of closely related male lineages were seen, with only 79.4% of donors displaying unique haplotypes and 59% of instances of shared haplotypes occurring within, rather than between, regions. Haplogroup prediction indicated diverse origins of the population with a predominance of haplogroups J2 and J1, both typical of the Arabian Peninsula, but also haplogroups such as B2 and E1b1a likely originating in Africa, and H, L and R2 likely indicative of migration from South Asia. Haplogroup frequencies differed significantly between regions, with J2 significantly more common in the Northern region compared with the Southern, possibly due to differential settlement by Baharna and Arabs. Our study shows that paternal lineage population structure can exist even over small geographical scales, and that highly discriminating genetic tools are required where rapid expansions have occurred within tightly bounded populations.

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Section: Resultsmentioning

confidence: 99%

Geographical structuring and low diversity of paternal lineages in Bahrain shown by analysis of 27 Y-STRs

et al. 2020

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“…32,33 In the past few years, a larger number of studies have investigated Y-STR data from countries and regions in vicinity of Iran and beyond. This includes studies on Armenia/Turkey/Caucasus/Georgia, [34][35][36] Afghanistan, 37 and Arab countries, 32,[38][39][40] as well as Russia, 41 whose southern part is considered to have hosted the speakers of Proto-Indo-European (PIE), Pakistan, 42 India, 43 Greece, 44 the Levant, 45 Central Asian Uyghurs 46 and East and West Africans. 47,48 Nevertheless, Y-STR data from Iran are sparse, both with respect to the geographical and ethnical coverage.…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of 27 Y-STR Haplotypes in 11 Iranian Ethnic Groups

Alinaghi,

Mohseni,

Fattahi

et al. 2024

Arch Iran Med

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Background: The study of Y-chromosomal variations provides valuable insights into male susceptibility in certain diseases like cardiovascular disease (CVD). In this study, we analyzed paternal lineage in different Iranian ethnic groups, not only to identify developing medical etiology, but also to pave the way for gender-specific targeted strategies and personalized medicine in medical genetic research studies. Methods: The diversity of eleven Iranian ethnic groups was studied using 27 Y-chromosomal short tandem repeat (Y-STR) haplotypes from Y-filer® Plus kit. Analysis of molecular variance (AMOVA) based on pair-wise RST along with multidimensional scaling (MDS) calculation and Network phylogenic analysis was employed to quantify the differences between 503 unrelated individuals from each ethnicity. Results: Results from AMOVA calculation confirmed that Gilaks and Azeris showed the largest genetic distance (RST=0.35434); however, Sistanis and Lurs had the smallest considerable genetic distance (RST=0.00483) compared to other ethnicities. Although Azeris had a considerable distance from other ethnicities, they were still close to Turkmens. MDS analysis of ethnic groups gave the indication of lack of similarity between different ethnicities. Besides, network phylogenic analysis demonstrated insignificant clustering between samples. Conclusion: The AMOVA analysis results explain that the close distance of Azeris and Turkmens may be the effect of male-dominant expansions across Central Asia that contributed to historical and demographics of populations in the region. Insignificant differences in network analysis could be the consequence of high mutation events that happened in the Y-STR regions over the years. Considering the ethnic group affiliations in medical research, our results provided an understanding and characterization of Iranian male population for future medical and population genetics studies.

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