A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

Rogers, Jeffrey; Mahaney, Michael C.; Witte, Shelly M.; Nair, Shalini; Newman, Deborah; Wedel, Steven; Rodriguez, Lawrence A.; Rice, Karen; Slifer, Susan H.; Perelygin, Andrey A.; Slifer, Michael A.; Palladino-Negro, Paula; Newman, Timothy K.; Chambers, Karen E.; Joslyn, Geoff; Parry, Pauline; Morin, Phillip A.

doi:10.1006/geno.2000.6245

Cited by 154 publications

(133 citation statements)

References 37 publications

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“…In the present study, the expression levels of human resistin transcripts in lymphocytes seemed to be regulated by the same gene region that influenced its expression in omental adipose tissue in baboons (Tejero et al, 2005). As described by Rogers et al (2000) the baboon orthologue of human chromosome 19 exhibits the same order among microsatellite markers that is found in the human genome. According to results in both species, the genetic variation influencing the expression of resistin mRNA is located in the 19p13 region, where the RETN gene is located, suggesting that the regulatory element is cis-acting.…”

Section: Discussionsupporting

confidence: 61%

“…The similarity in the genomes between these two species permits replication of results (Rogers et al, 2000). A previous replication of linkage between the two species has been found using the bone marker osteocalcin, a protein used as a serum marker of osteoblast activity.…”

Section: Discussionmentioning

confidence: 83%

“…The genetic and physiologic similarity between baboons and humans has been demonstrated in various studies (Rogers et al, 2000;Banks et al, 2003;Tejero et al, 2004, Chavez et al, 2008. The similarity in the genomes between these two species permits replication of results (Rogers et al, 2000).…”

Section: Discussionmentioning

confidence: 90%

“…The baboon has been used as a model for the study of obesity and insulin resistance due to its genetic and physiologic similarity to humans (Rogers et al, 2000;Banks et al, 2003;Chavez et al, 2008). In both humans and baboons the metabolic response to an increase in body weight is characterized by augmentation of body fat percentage, circulating levels of insulin, insulin resistance, glucose, lipids and lower levels of adiponectin (Banks et al, 2003;Comuzzie et al, 2003;Tejero et al, 2004;Chavez et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

et al. 2008

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

et al. 2008

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“…Emerging evidence suggests that genetic factors may modulate individual differences in responses to stress and perhaps, the adverse health consequences associated with chronic stress exposure [7,8]. Variation in serotonin (5HT) neurotransmission is one such factor, as 5HT can limit responses to acute stress [9], and its activity is compromised during chronic stress [10,11].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys

Jarrell¹,

Hoffman²,

Kaplan³

et al. 2008

Physiology & Behavior

109

163

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Individuals vary substantially in their vulnerability to physical and psychosocial stressors. The causes of such variation in susceptibility to stress are poorly understood, but are thought to relate in part to genetic factors. The present study evaluated the extent to which polymorphisms in the gene encoding the serotonin reuptake transporter (5HTTLPR or SERT) modulated physiologic responses to the imposition of psychosocial stress (social reorganization and subordinate social status) in female rhesus monkeys. Forty females, drawn from the middle ranking genealogies of several large social groups, were reorganized into eight groups containing 5 monkeys each; four groups were comprised entirely of animals homogeneous for the long promoter variant in the SERT gene (l/l), while the other four groups had monkeys with at least one allele of the short promoter variant (l/s or s/s). Females were sequentially introduced into these new groups in random order and dominance ranks were established within several days. During the ensuing 6 weeks, dominant monkeys exhibited elevated rates of aggression while subordinates displayed high rates of submission. Notably, females with the s-variant SERT genotype, collapsed across social status positions, exhibited the highest overall rates of both aggression and submission. Although neither social status nor SERT genotype influenced morning cortisol concentrations, glucocorticoid negative feedback was reduced significantly in subordinate compared to dominant females irrespective of genotype. All animals lost weight and abdominal fat across the experiment. However, decreases were greatest in subordinates, regardless of genotype, and least in dominant females with the l/l genotype. Serum concentrations of insulin, glucose, and ghrelin decreased significantly during the group formation process, effects that were independent of genotype or social status. In contrast, social status and genotype interacted to influence changes in serum concentrations of leptin and triiodothyronine (T3), as dominant, l/l females had the highest levels while subordinate s-variant females had the lowest levels. The order in which a female was introduced to her group generally predicted her eventual social rank. However, rank was additionally predicted by pre-experimental T3 and abdominal fat values, but only in the l/l animals. While these findings must be replicated with a larger sample size, the data suggest that the s-variant SERT genotype confers increased vulnerability to the adverse effects of psychosocial stress associated with subordinate status while the l/l genotype benefits the most from the absence of stress conferred by dominant social status. These findings suggest that genetic factors modify the responses of monkeys to social subordination and perhaps other psychosocial stressors.

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A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype

Dudley

Hubbard

Moore

et al. 2005

American J of Med Genetics Pt A

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A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

Cited by 154 publications

References 37 publications

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys

A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype

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