A genetic heritage; the same yet different: A comparative study in twins

Mas, Catherine; Frapier, Laure

doi:10.1016/j.ortho.2017.06.021

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…2,3,21 Epigenetics stands out as one of the most studied current branches, demonstrating that gene expression can be influenced by environmental factors. 5,15,22 Several studies have also been carried out on pairs of monozygotic and dizygotic twins in order to demonstrate the contribution of genetics to the development of dentition and occlusion. 9,[12][13][14][15][16]23 In relation to the development of supernumerary teeth, some studies claim that their etiology is not yet fully elucidated, but they believe that they can be transmitted as an autosomal dominant trait lacking penetrance in some generations.…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic aspects related to malocclusion–report of cases of monozygotic twins

Carvalho

Damasceno

Couto

et al. 2019

BJHR

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Introduction: The multifactorial etiology of malocclusion involves several factors such as genetic, epigenetic and environmental factors. Among various dental anomalies, the development of supernumerary teeth is also directly related to genetic factors and mesiodens is the most frequent type of anomaly. Case Report: Two monozygotic twin sisters, both of which presented mesiodens, but only one with associated anterior open bite. Supernumerary removal was performed in the two sisters, and the anterior open bite was treated with the use of a fixed palatine grid. Results: The case was finished with proper occlusion and intercuspidation, contemplating facial and dental esthetics. Conclusion: Observing the possible differences that occur in pairs of monozygotic twins, it can be concluded that the development of malocclusions is associated with an interaction between genetic, epigenetic and environmental factors. Thus, the diagnosis and treatment of malocclusion should be individualized for each patient.

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Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic aspects related to malocclusion–report of cases of monozygotic twins

Carvalho

Damasceno

Couto

et al. 2019

BJHR

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“…Recently, Šidlauskas et al observed that the shape and sagittal position of the mandible were strongly influenced by genetic factors in 141 same‐sex adult pairs of twins (Šidlauskas et al, 2016). The differences in the skeletal discrepancies in the sagittal and vertical dimensions could be explained by the interaction of genetic and epigenetic factors with environmental influences (Mas & Frapier, 2017). Significant genetic effects on linear cephalometric variables, including the length of the cranial base, maxillary length, and mandibular length were proven in 52 pairs of twin studies (Tiro et al, 2019).…”

Section: Genetic Variants Associated With Skeletal Class III Malocclu...mentioning

confidence: 99%

Genetic architecture of non‐syndromic skeletal class III malocclusion

et al. 2022

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Non‐syndromic skeletal Class III malocclusion is a major craniofacial disorder characterized by genetic and environmental factors. Patients with severe skeletal Class III malocclusion require orthognathic surgery to obtain aesthetic facial appearance and functional occlusion. Recent studies have demonstrated that susceptible chromosomal regions and genetic variants of candidate genes play important roles in the etiology of skeletal Class III malocclusion. Here, we provide a comprehensive review of our current understanding of the genetic factors that affect non‐syndromic skeletal Class III malocclusion, including the patterns of inheritance and multiple genetic approaches. We then summarize the functional studies on related loci and genes using cell biology and animal models, which will help to implement individualized therapeutic interventions.

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“…addressing dento-craniofacial structures in monozygotic twins may be an important way to analyze and evaluate the impact of genetic and environmental factors on the individuals` phenotypic development [7], [8], [1]. Monozygotic twins originate from the fertilization of a single egg, which in the early embryogenesis stages, splits into two identical embryos [9], [10].…”

Section: Researchmentioning

confidence: 99%

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Gomes¹,

Souza²,

Gomes³

et al. 2020

JAMMR

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Introduction: Monozygotic twins are a valuable sample for the study of human craniofacial growth and development. Aims: The aim of the present study was to analyze the dento-craniofacial characteristics in monozygotic twins and to discuss the genetic, epigenetic and environmental influences in the twin’s phenotypic features. Material and Methods: Two 21-year-old female twins attended the Dental Service of Universidade Federal dos Vales do Jequitinhonha e Mucuri were analyzed. For validation of this study, a genetic test of zygosity was performed to confirm the individuals' monozygosity. Intraoral buccal examination revealed occlusal differences as well as disagreement in the eruption of the third molars. Results: The analysis of models showed differences in the mesio-distal diameter of the teeth of both arches, as well as disagreement in the perimeter of the mandibular arches between the two individuals. The cephalometric analysis showed remarkable differences in the vertical and horizontal parameters of the craniofacial structure. The SNA, SNB and LAFH showed differences of 10º, 9º and 3mm respectively. Additionally, the components related to the dentition also showed discrepant results. Conclusion: It can be suggested that the dento-craniofacial characteristics present a genetic component; however, the interaction of epigenetic and environmental factors can lead to different phenotypes in univiteline twins.

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A genetic heritage; the same yet different: A comparative study in twins

Cited by 3 publications

References 16 publications

Genetic and epigenetic aspects related to malocclusion–report of cases of monozygotic twins

Genetic and epigenetic aspects related to malocclusion–report of cases of monozygotic twins

Genetic architecture of non‐syndromic skeletal class III malocclusion

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

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