Abstract:The transcription factor, hypoxia‐inducible factor (HIF) regulates the expression of a number of metabolic genes. In the recessive condition of Chuvash Polycythemia (CP), the normal degradation of HIF in euoxia is slowed by functional mutation within the von Hippel‐Lindau (VHL) gene. Thus the disease of CP provides an opportunity to understand the role of the HIF‐VHL pathway in metabolic regulation at a systemic level. We recruited 5 CP patients and 5 controls, matched for gender, and similar for age, height a… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.