A Genetic Basis for Tumour Suppression

Stanbridge, Eric J.

doi:10.1002/9780470513750.ch10

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Retinoblastoma and the RB1 tumor suppressor gene led to a paradigm shift in cancer genetics in the late 1980s and early 1990s, with increased acceptance and understanding of the concept and molecular function of tumor suppressor genes [30]. This paved the way for further research to discover other human tumor suppressor genes, the mechanisms of tumorigenesis in human cancers and, particularly, the role of the retinoblastoma protein (pRB) in retinoblastoma and other cancers [31].…”

Section: Discussionmentioning

confidence: 99%

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene

Berry

Polski

Cavenee

et al. 2019

Genes

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The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have laid the foundation for numerous advances in the understanding of tumor suppressor genes, retinoblastoma tumorigenesis, and inheritance. Knowledge of RB1 led to a paradigm shift in the field of cancer genetics, including widespread acceptance of the concept of tumor suppressor genes, and has provided crucial diagnostic and prognostic information through genetic testing for patients affected by retinoblastoma. This article reviews the long history of RB1 gene research, characterization, and cloning, and also discusses recent advances in retinoblastoma genetics that have grown out of this foundational work.

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Section: Discussionmentioning

confidence: 99%

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene

Berry

Polski

Cavenee

et al. 2019

Genes

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Frontiers in mammalian cells culture

McKeehan

Barnes

Reid

et al. 1990

In Vitro Cell Dev Biol

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For the past 60 years, fundamental discoveries in eukaryotic biology using mammalian cell cultures have been significant but modest relative to the enormous potential. Combined with advances in technologies of cell and molecular biology, mammalian cell culture technology is becoming a major, if not essential tool, for fundamental discovery in eukaryotic biology. Reconstruction of the milieu for cells has progressed from simple salt solutions supporting brief survival of tissues outside the body to synthesis of the complete set of structurally defined nutrients, hormones and elements of the extracellular matrix needed to reconstruct complex tissues from cells. The isolation of specific cell types in completely defined environments reveals the true complexity of the mammalian cell and its environment as a dynamic interactive physiological unit. Cell cultures provide the tool for detection and dissection of the mechanism of action of cellular regulators and the genes that determine individual aspects of cell behavior. The technology underpins advances in virology, somatic cell genetics, endocrinology, carcinogenesis, toxicology, pharmacology, hematopoiesis and immunology, and is becoming a major tool in developmental biology, complex tissue physiology and production of unique mammalian cell-derived biologicals in industry.

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Contributions of the Gordon‐Kosswig Melanoma System to the Present Concept of Neoplasia

Anderš

1991

Pigment Cell Research

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Modern cancerology is based on the oncogene concept. This is rather new. The idea of the oncogene, however, is old, and can be traced back to two sources, namely to "cancer families," reported in 1866 by P. Broka, and to "virus induced" neoplasia, detected by P. Rous in 1911. A gene which is--to my knowledge--the first reported oncogene by definition was detected in the little ornamental Mexican fish Xiphophorus by Myron Gordon, Curt Kosswig, and Georg Häussler in 1928 when they observed the terrible hereditary melanomas that we are now coming to understand and to compare with other kinds of neoplasms in Xiphophorus and in mammals, including humans. Although the Xiphophorus model was always modest in its claims, it has--sometimes too early in its history--contributed many facts to the present concept of neoplasia.

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A Genetic Basis for Tumour Suppression

Cited by 3 publications

References 43 publications

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene

Frontiers in mammalian cells culture

Contributions of the Gordon‐Kosswig Melanoma System to the Present Concept of Neoplasia

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