“…In these PPI networks, the active module search aims to find disease-related subnetworks that contain most of the highly affected nodes (proteins) and their interaction partners with medium effect on the disease [2]. The active subnetwork search problem requires two main inputs, i) protein-protein interaction network, ii) node scores of proteins that indicate the statistical significance of a protein for the disease under investigation [3]- [5]. Most methods often use undirected graphs of protein-protein interaction networks and the node scores are used as the weight of the nodes.…”